Protein: GABPA
GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60)

Gene: GABPA
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q06546

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1055590

GABP1
GA-binding protein subunit beta-1

8

6

Small-scale

0.968

High

1055620

GABP2
GA-binding protein subunit beta-2

4

4

High-throughput

0.898

High

1055639

FOXJ2
Forkhead box protein J2

1

11

High-throughput

0.691

High

1055591

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.672

High

340321

YETS4
YEATS domain-containing protein 4

3

1

High-throughput

0.667

High

1055600

KEAP1
Kelch-like ECH-associated protein 1

3

4

Small-scale

0.640

High

1055601

FHL2
Four and a half LIM domains protein 2

2

3

Small-scale

0.619

High

738972

ELF1
ETS-related transcription factor Elf-1

1

16

High-throughput

0.618

High

832514

ETV3
ETS translocation variant 3

1

17

High-throughput

0.618

High

837040

ELK3
ETS domain-containing protein Elk-3

1

17

High-throughput

0.618

High

1055589

GABPA
GA-binding protein alpha chain

1

19

Small-scale

0.618

High

1055606

ELF2
ETS-related transcription factor Elf-2

1

18

High-throughput

0.618

High

1055633

FEV
Protein FEV

1

17

High-throughput

0.618

High

1055634

ELF4
ETS-related transcription factor Elf-4

1

18

High-throughput

0.618

High

1055594

SKP2
S-phase kinase-associated protein 2

2

11

Small-scale

0.612

High

291780

STK16
Serine/threonine-protein kinase 16

2

1

High-throughput

0.606

High

1055603

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

464930

SP1
Transcription factor Sp1

1

20

Small-scale

0.578

High

1036869

SP3
Transcription factor Sp3

1

20

Small-scale

0.578

High

215419

TPD54
Tumor protein D54

2

1

High-throughput

0.574

High

395975

ESR1
Estrogen receptor

2

15

High-throughput

0.571

High

1055605

MED1
Mediator of RNA polymerase II transcription subunit 1

1

20

Small-scale

0.561

High

905386

HCFC1
Host cell factor 1

1

5

Small-scale

0.560

High

634734

ITAX
Integrin alpha-X

1

2

Small-scale

0.553

High

1055630

TPD55
Tumor protein D55

2

1

High-throughput

0.549

High

126236

ST2B1
Sulfotransferase 2B1

1

3

High-throughput

0.536

High

369453

AACT
Alpha-1-antichymotrypsin

1

6

High-throughput

0.536

High

424183

S10A8
Protein S100-A8

1

6

High-throughput

0.536

High

444963

S10A9
Protein S100-A9

1

8

High-throughput

0.536

High

577726

PLAK
Junction plakoglobin

1

4

High-throughput

0.536

High

682479

S100P
Protein S100-P

1

8

High-throughput

0.536

High

713369

SPB3
Serpin B3

1

5

High-throughput

0.536

High

724563

S10A7
Protein S100-A7

1

8

High-throughput

0.536

High

930858

HSP72
Heat shock-related 70 kDa protein 2

1

6

High-throughput

0.536

High

1023314

ZN200
Zinc finger protein 200

1

3

High-throughput

0.536

High

1055597

PKP1
Plakophilin-1

1

4

High-throughput

0.536

High

1055602

GBX1
Homeobox protein GBX-1

1

16

High-throughput

0.536

High

1055626

KLK6
Kallikrein-6

1

5

High-throughput

0.536

High

1055629

GASP2
G-protein coupled receptor-associated sorting protein 2

1

1

High-throughput

0.536

High

1055642

SPB13
Serpin B13

1

5

High-throughput

0.536

High

886789

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.527

High

1055628

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.518

High

553714

ANXA3
Annexin A3

1

0

High-throughput

0.513

High

582570

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

627125

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

671778

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

711701

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.513

High

1055638

IL36G
Interleukin-36 gamma

1

0

High-throughput

0.513

High

421980

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

617096

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

7

Small-scale

0.501

High

85977

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

2

High-throughput

0.489

High

261616

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

289253

SPB7
Serpin B7

1

6

High-throughput

0.489

High

423766

APOD
Apolipoprotein D

1

2

High-throughput

0.489

High

457858

INVO
Involucrin

1

10

High-throughput

0.489

High

485788

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

649728

SPR1B
Cornifin-B

1

1

High-throughput

0.489

High

706107

S10A2
Protein S100-A2

1

8

High-throughput

0.489

High

770666

SPR1A
Cornifin-A

1

1

High-throughput

0.489

High

868083

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.489

High

874777

SPB4
Serpin B4

1

5

High-throughput

0.489

High

892099

KLK7
Kallikrein-7

1

4

High-throughput

0.489

High

1009640

NGAL
Neutrophil gelatinase-associated lipocalin

1

3

High-throughput

0.489

High

1055607

CYTM
Cystatin-M

1

1

High-throughput

0.489

High

1055608

PA24E
Cytosolic phospholipase A2 epsilon

1

2

High-throughput

0.489

High

1055609

KPRP
Keratinocyte proline-rich protein

1

1

High-throughput

0.489

High

1055611

CORO6
Coronin-6

1

9

High-throughput

0.489

High

1055616

S1A7A
Protein S100-A7A

1

8

High-throughput

0.489

High

1055617

SPA9
Serpin A9

1

6

High-throughput

0.489

High

1055618

PA24D
Cytosolic phospholipase A2 delta

1

4

High-throughput

0.489

High

1055625

EVPL
Envoplakin

1

2

High-throughput

0.489

High

1055631

CPNS2
Calpain small subunit 2

1

1

High-throughput

0.489

High

1055632

GSDMA
Gasdermin-A

1

1

High-throughput

0.489

High

1055636

S10AE
Protein S100-A14

1

8

High-throughput

0.489

High

1055645

FCGBP
IgGFc-binding protein

1

1

High-throughput

0.489

High

185630

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

142960

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

188254

HDAC3
Histone deacetylase 3

1

8

Small-scale

0.479

High

190885

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

241481

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

339726

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

371845

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

473939

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

606676

CEBPB
CCAAT/enhancer-binding protein beta

1

9

Small-scale

0.479

High

612999

EGR1
Early growth response protein 1

1

8

High-throughput

0.479

High

675473

TYY1
Transcriptional repressor protein YY1

1

10

Small-scale

0.479

High

789097

NUP62
Nuclear pore glycoprotein p62

1

8

High-throughput

0.479

High

879002

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

13

High-throughput

0.479

High

944636

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

986363

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

998243

H31
Histone H3.1

1

12

High-throughput

0.479

High

1016797

H33
Histone H3.3

1

12

High-throughput

0.479

High

1055592

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1055593

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1055595

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.479

High

1055596

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

1055598

KLF9
Krueppel-like factor 9

1

20

High-throughput

0.479

High

1055619

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.479

High

1055621

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1055624

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

1055627

LHX4
LIM/homeobox protein Lhx4

1

6

High-throughput

0.479

High

1055635

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

1055640

LHX3
LIM/homeobox protein Lhx3

1

6

High-throughput

0.479

High

1055643

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1055644

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

718689

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

1

Small-scale

0.470

High

695283

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768023

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1055604

ELOB
Elongin-B

1

0

High-throughput

0.458

High

75666

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

850866

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

2

Small-scale

0.437

High

1055613

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

69490

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

379094

IGKC
Immunoglobulin kappa constant

1

2

High-throughput

0.407

High

379240

IGHG1
Immunoglobulin heavy constant gamma 1

1

2

High-throughput

0.407

High

1055610

ZC21B
Zinc finger C2HC domain-containing protein 1B

2

0

High-throughput

0.316

High

1055599

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

0

Small-scale

0.305

High

276583

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

609306

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

652306

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

692687

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1055612

ACP7
Acid phosphatase type 7

1

0

High-throughput

0.279

Low

1055614

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

1055615

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

1055622

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1055623

CV015
Uncharacterized protein C22orf15

1

0

High-throughput

0.279

Low

1055637

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.279

Low

1055641

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

239453

AGRB2
Adhesion G protein-coupled receptor B2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025