HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: TOPRS (Q9NS56)
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
Gene: TOPORS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 152 Hs			1 1045
+	Hs
		1345306 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		849457 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		919873 UB2D2_HUMAN (4-149): 9.96e-80: 233: 46.58		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		895925 UB2D3_HUMAN (4-149): 1.46e-78: 230: 45.89		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		1282352 UB2E3_HUMAN (1-149): 3.17e-75: 224: 44.97		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		851891 UB2E1_HUMAN (1-149): 1.93e-73: 219: 45.64		TOPRS_HUMAN (1-1045): 0: 731: 100.00