Protein: MINK1
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)

Gene: MINK1
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q8N4C8

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001952 - regulation of cell-matrix adhesion
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

348164

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

4

17

High-throughput

0.900

High

375717

RASK
GTPase KRas

3

20

High-throughput

0.827

High

1326457

TNIK
TRAF2 and NCK-interacting protein kinase

2

17

High-throughput

0.811

High

518612

RAP2A
Ras-related protein Rap-2a

2

19

Small-scale

0.783

High

349159

LATS1
Serine/threonine-protein kinase LATS1

2

20

Small-scale

0.778

High

374052

RASN
GTPase NRas

2

20

High-throughput

0.754

High

374759

RASH
GTPase HRas

2

20

High-throughput

0.754

High

978160

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

222144

NCK2
Cytoplasmic protein NCK2

5

20

High-throughput

0.712

High

868329

V1BR
Vasopressin V1b receptor

1

1

High-throughput

0.691

High

1107921

SQSTM
Sequestosome-1

1

7

High-throughput

0.691

High

1243422

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

9

High-throughput

0.691

High

1326427

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

4

High-throughput

0.691

High

1326452

STK26
Serine/threonine-protein kinase 26

1

20

High-throughput

0.691

High

1217340

STRP1
Striatin-interacting protein 1

3

14

High-throughput

0.681

High

1326446

STRN4
Striatin-4

3

20

High-throughput

0.681

High

228610

STRN
Striatin

3

20

High-throughput

0.667

High

1092901

STRN3
Striatin-3

3

20

High-throughput

0.667

High

1326422

CNOT9
CCR4-NOT transcription complex subunit 9

3

1

High-throughput

0.667

High

1326468

PHOCN
MOB-like protein phocein

3

20

High-throughput

0.667

High

1326474

TX264
Testis-expressed protein 264

3

1

High-throughput

0.667

High

1326470

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.656

High

64067

CNOT1
CCR4-NOT transcription complex subunit 1

2

1

High-throughput

0.628

High

273898

CNOT3
CCR4-NOT transcription complex subunit 3

2

12

High-throughput

0.628

High

949499

NANO2
Nanos homolog 2

2

1

High-throughput

0.628

High

1326435

TB182
182 kDa tankyrase-1-binding protein

2

5

High-throughput

0.628

High

1326450

CNOT2
CCR4-NOT transcription complex subunit 2

2

2

High-throughput

0.628

High

1326458

CNO11
CCR4-NOT transcription complex subunit 11

2

1

High-throughput

0.628

High

594048

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.626

High

126695

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

440144

LCK
Tyrosine-protein kinase Lck

1

15

High-throughput

0.618

High

461700

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.618

High

463648

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

468590

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.618

High

541588

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

581164

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601371

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

625490

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.618

High

631339

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.618

High

710363

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

931869

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.618

High

936384

AFAD
Afadin

1

20

High-throughput

0.618

High

953560

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

988524

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

995136

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.618

High

997854

CSK21
Casein kinase II subunit alpha

1

13

High-throughput

0.618

High

1145010

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

1147376

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

1151775

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1156996

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1159515

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1326416

MINK1
Misshapen-like kinase 1

1

16

High-throughput

0.618

High

1326421

DNJC9
DnaJ homolog subfamily C member 9

1

3

High-throughput

0.618

High

1326434

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.618

High

1326437

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.618

High

1326438

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1326439

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1326442

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

283706

GPC4
Glypican-4

2

1

High-throughput

0.611

High

1326453

CT2NL
CTTNBP2 N-terminal-like protein

2

20

High-throughput

0.611

High

294734

PR15A
Protein phosphatase 1 regulatory subunit 15A

2

0

High-throughput

0.602

High

1326456

CNOT7
CCR4-NOT transcription complex subunit 7

2

0

High-throughput

0.602

High

991623

DYL1
Dynein light chain 1, cytoplasmic

2

10

High-throughput

0.601

High

975124

ARF6
ADP-ribosylation factor 6

2

8

High-throughput

0.584

High

255124

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.575

High

396501

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

1219254

IER5
Immediate early response gene 5 protein

2

0

Small-scale

0.569

High

829459

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

1

High-throughput

0.558

High

935916

ECHB
Trifunctional enzyme subunit beta, mitochondrial

2

2

High-throughput

0.558

High

1326418

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.558

High

966607

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

1049553

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

85537

HNRC3
Heterogeneous nuclear ribonucleoprotein C-like 3

1

5

High-throughput

0.553

High

845720

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.553

High

1028676

U2AF1
Splicing factor U2AF 35 kDa subunit

1

1

High-throughput

0.553

High

1144635

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

5

High-throughput

0.553

High

124941

GTPB1
GTP-binding protein 1

1

6

High-throughput

0.536

High

239130

ZNRD2
Protein ZNRD2

1

3

High-throughput

0.536

High

325926

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

414201

P53
Cellular tumor antigen p53

1

2

High-throughput

0.536

High

786168

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.536

High

867272

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

881722

FNTB
Protein farnesyltransferase subunit beta

1

1

High-throughput

0.536

High

925949

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

938171

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.536

High

1041171

CAV1
Caveolin-1

1

7

High-throughput

0.536

High

1102207

ATM
Serine-protein kinase ATM

1

1

High-throughput

0.536

High

1119091

RPGF1
Rap guanine nucleotide exchange factor 1

1

3

High-throughput

0.536

High

1144071

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1179230

ERC6L
DNA excision repair protein ERCC-6-like

1

5

High-throughput

0.536

High

1179815

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.536

High

1239873

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.536

High

1252892

BAKOR
Beclin 1-associated autophagy-related key regulator

1

2

High-throughput

0.536

High

1307158

GLT13
Polypeptide N-acetylgalactosaminyltransferase 13

1

1

High-throughput

0.536

High

1326424

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.536

High

1326436

CPVL
Probable serine carboxypeptidase CPVL

1

4

High-throughput

0.536

High

1326440

SH24A
SH2 domain-containing protein 4A

1

20

High-throughput

0.536

High

1326444

WDR6
tRNA

1

10

High-throughput

0.536

High

1326463

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.536

High

1326465

KLH20
Kelch-like protein 20

1

3

High-throughput

0.536

High

1326467

SGT1
Protein SGT1 homolog

1

8

High-throughput

0.536

High

1326473

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

1026462

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.527

High

730766

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

971777

1433E
14-3-3 protein epsilon

1

14

High-throughput

0.515

High

1022910

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

1243114

ALKB5
RNA demethylase ALKBH5

1

0

High-throughput

0.513

High

1326432

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.513

High

1326441

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.513

High

1326425

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.501

High

1326429

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

High-throughput

0.501

High

1326428

FACOS
FANCD2 opposite strand protein

1

1

High-throughput

0.489

High

1326459

ABT1
Activator of basal transcription 1

1

4

High-throughput

0.489

High

1326462

T3JAM
TRAF3-interacting JNK-activating modulator

1

20

High-throughput

0.489

High

1326464

SL9A8
Sodium/hydrogen exchanger 8

1

3

High-throughput

0.489

High

1326472

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

1

High-throughput

0.489

High

126147

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.479

High

299286

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

331141

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

346066

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

556212

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

562222

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

High-throughput

0.479

High

574369

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.479

High

582878

EZRI
Ezrin

1

11

High-throughput

0.479

High

604091

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

642970

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

691241

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

730052

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

880338

RL34
Large ribosomal subunit protein eL34

1

1

High-throughput

0.479

High

941807

ARL4C
ADP-ribosylation factor-like protein 4C

1

15

High-throughput

0.479

High

961775

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.479

High

984467

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

985501

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.479

High

987773

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

990494

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1005915

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

1035774

KIF23
Kinesin-like protein KIF23

1

18

High-throughput

0.479

High

1057210

PRDX1
Peroxiredoxin-1

1

5

High-throughput

0.479

High

1187494

AR13B
ADP-ribosylation factor-like protein 13B

1

15

High-throughput

0.479

High

1233348

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

1258346

MOB3C
MOB kinase activator 3C

1

20

High-throughput

0.479

High

1287067

MOB3B
MOB kinase activator 3B

1

20

High-throughput

0.479

High

1326417

ARL14
ADP-ribosylation factor-like protein 14

1

9

High-throughput

0.479

High

1326426

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.479

High

1326443

E41LA
Band 4.1-like protein 4A

1

10

High-throughput

0.479

High

1326447

FGOP2
FGFR1 oncogene partner 2

1

15

High-throughput

0.479

High

1326448

ARL15
ADP-ribosylation factor-like protein 15

1

11

High-throughput

0.479

High

1326451

RCC2
Protein RCC2

1

5

High-throughput

0.479

High

1326455

XPO7
Exportin-7

1

11

High-throughput

0.479

High

1326460

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.479

High

1326466

AP3M1
AP-3 complex subunit mu-1

1

2

High-throughput

0.479

High

1326469

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.479

High

1326471

DCAF1
DDB1- and CUL4-associated factor 1

1

4

High-throughput

0.479

High

1326445

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

58871

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

934855

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

106263

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

329770

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

1

High-throughput

0.437

High

589152

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

1159752

OCLN
Occludin

1

6

High-throughput

0.437

High

1276478

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1322887

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.437

High

1326419

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.437

High

1326423

ESR2
Estrogen receptor beta

1

12

High-throughput

0.437

High

1326430

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.437

High

1326431

CHOLN
Protein cholesin

1

2

High-throughput

0.437

High

1326454

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

3

High-throughput

0.437

High

1326461

SRRM2
Serine/arginine repetitive matrix protein 2

1

6

High-throughput

0.437

High

1326449

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.407

High

1326420

SEN15
tRNA-splicing endonuclease subunit Sen15

2

0

High-throughput

0.328

High

608303

EGLN
Endoglin

1

0

High-throughput

0.279

Low

653435

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.279

Low

659689

NFYA
Nuclear transcription factor Y subunit alpha

1

0

High-throughput

0.279

Low

377654

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

488327

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.249

Low

1326433

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025