HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	34079125, 12176742, 37071682, 11018051, 35271311, 30562756, 11231575, 12732638
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0030027 - lamellipodium GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 550
+	Mm
		1141103 ARP3_MOUSE (1-418): 0: 588: 99.76		SRC8_MOUSE (1-550): 0: 548: 92.18
+	Hs
		891762 ACTB_HUMAN (1-414): 0: 539: 35.66		SRC8_HUMAN (1-550): 0: 559: 100.00
+	Hs
		929863 ACTG_HUMAN (1-414): 0: 538: 35.42		SRC8_HUMAN (1-550): 0: 559: 100.00
+	Hs
		536573 ARP3_HUMAN (1-418): 0: 588: 100.00		HCLS1_HUMAN (1-550): 7.82e-141: 417: 37.50
+	Hs
		896843 ARP3_HUMAN (1-418): 0: 588: 100.00		DBNL_HUMAN (359-550): 8.22e-32: 129: 32.21
+	Hs
		930053 ACTG_HUMAN (1-414): 0: 538: 35.42		PACN2_HUMAN (176-550): 4.93e-40: 153: 15.37
+	Hs
		891755 ACTB_HUMAN (1-414): 0: 539: 35.66		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		929856 ACTG_HUMAN (1-414): 0: 538: 35.42		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		207785 ACTB_HUMAN (1-414): 0: 539: 35.66		PPIP1_HUMAN (198-549): 4.97e-33: 132: 15.18
+	Hs
		892099 ACTB_HUMAN (1-414): 0: 539: 35.66		DBNL_HUMAN (359-550): 8.22e-32: 129: 32.21
+	Hs
		932975 ACTS_HUMAN (3-414): 0: 528: 35.59		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		932145 ACTC_HUMAN (3-414): 0: 527: 35.59		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		929985 ACTG_HUMAN (1-414): 0: 538: 35.42		SH3G2_HUMAN (365-549): 1.87e-31: 126: 17.28
+	Hs
		896741 ARP3_HUMAN (1-418): 0: 588: 100.00		LASP1_HUMAN (358-547): 4.29e-13: 71.4: 22.93
+	Hs
		892072 ACTB_HUMAN (1-414): 0: 539: 35.66		ABI2_HUMAN (396-547): 4.11e-13: 73.7: 29.68
+	Hs
		930026 ACTG_HUMAN (1-414): 0: 538: 35.42		ABI2_HUMAN (396-547): 4.11e-13: 73.7: 29.68
+	Hs
		891770 ACTB_HUMAN (1-414): 0: 539: 35.66		LASP1_HUMAN (358-547): 4.29e-13: 71.4: 22.93
+	Ce
		501469 ACT2_CAEEL (3-414): 0: 536: 36.08		Q9XUT0_CAEEL (329-548): 5.19e-13: 73.7: 23.65
+	Ce
		70025 ACT4_CAEEL (3-414): 0: 535: 36.08		SH3GH_CAEEL (358-548): 3.11e-12: 70.2: 22.00
+	Hs
		235496 ACTS_HUMAN (3-414): 0: 528: 35.59		VINEX_HUMAN (254-546): 4.43e-13: 73.9: 13.51