HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25982273
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 261
+	Hs
		891770 ACTB_HUMAN (1-414): 0: 539: 35.66		LASP1_HUMAN (1-261): 1.82e-58: 188: 100.00
+	Hs
		896843 ARP3_HUMAN (1-418): 0: 588: 100.00		DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65
+	Mm
		1141103 ARP3_MOUSE (1-418): 0: 588: 99.76		SRC8_MOUSE (59-260): 8.14e-23: 99.2: 21.68
+	Hs
		896739 ARP3_HUMAN (1-418): 0: 588: 100.00		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		896751 ARP3_HUMAN (1-418): 0: 588: 100.00		SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62
+	Hs
		896813 ARP3_HUMAN (1-418): 0: 588: 100.00		SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30
+	Hs
		596202 ACTB_HUMAN (1-414): 0: 539: 35.66		NEBU_HUMAN (15-261): 2.62e-29: 118: 29.11
+	Hs
		282322 ACTB_HUMAN (1-414): 0: 539: 35.66		NEBL_HUMAN (36-261): 8.63e-29: 116: 31.67
+	Hs
		207785 ACTB_HUMAN (1-414): 0: 539: 35.66		PPIP1_HUMAN (3-261): 4.41e-28: 112: 15.47
+	Hs
		892099 ACTB_HUMAN (1-414): 0: 539: 35.66		DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65
+	Hs
		892117 ACTB_HUMAN (1-414): 0: 539: 35.66		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		930056 ACTG_HUMAN (1-414): 0: 538: 35.42		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		891762 ACTB_HUMAN (1-414): 0: 539: 35.66		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		929863 ACTG_HUMAN (1-414): 0: 538: 35.42		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		929985 ACTG_HUMAN (1-414): 0: 538: 35.42		SH3G2_HUMAN (47-261): 5.88e-23: 98: 18.14
+	Ce
		70025 ACT4_CAEEL (3-414): 0: 535: 36.08		SH3GH_CAEEL (45-261): 5.46e-22: 95.7: 17.02
+	Dm
		501505 ACT1_DROME (3-414): 0: 534: 35.35		LASP1_DROME (52-259): 1.57e-17: 83.8: 24.04
+	Hs
		891821 ACTB_HUMAN (1-414): 0: 539: 35.66		SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62
+	Hs
		892005 ACTB_HUMAN (1-414): 0: 539: 35.66		SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30
+	Ce
		501469 ACT2_CAEEL (3-414): 0: 536: 36.08		Q9XUT0_CAEEL (122-261): 4.86e-13: 70.3: 26.17