HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: MICA3 (Q7RTP6)
[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
Gene: MICAL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 2002
+	Dm
		501502 ACT1_DROME (3-414): 0: 534: 35.35		MICAL_DROME (15-1980): 0: 795: 23.78
+	Hs
		521515 ARP3_HUMAN (1-418): 0: 588: 100.00		ACTN1_HUMAN (434-1065): 1.24e-103: 357: 14.97
+	Hs
		211548 ACTB_HUMAN (1-414): 0: 539: 35.66		ACTN4_HUMAN (434-1045): 2.63e-104: 359: 14.72
+	Hs
		725637 ACTB_HUMAN (1-414): 0: 539: 35.66		ACTN2_HUMAN (434-1002): 9.84e-104: 357: 15.81
+	Hs
		211561 ACTS_HUMAN (3-414): 0: 528: 35.59		ACTN4_HUMAN (434-1045): 2.63e-104: 359: 14.72
+	Hs
		211560 ACTC_HUMAN (3-414): 0: 527: 35.59		ACTN4_HUMAN (434-1045): 2.63e-104: 359: 14.72
+	Dm
		361167 ACT4_DROME (3-414): 0: 526: 35.35		ACTN_DROME (434-1093): 1.88e-99: 345: 14.02
+	Hs
		891697 ACTB_HUMAN (1-414): 0: 539: 35.66		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		929824 ACTG_HUMAN (1-414): 0: 538: 35.42		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		506816 ACTB_HUMAN (1-414): 0: 539: 35.66		SPTB1_HUMAN (433-1059): 1.05e-83: 309: 16.54
+	Hs
		932107 ACTC_HUMAN (3-414): 0: 527: 35.59		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		164588 ACTB_HUMAN (1-414): 0: 539: 35.66		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Oc
		933099 ACTS_RABIT (3-414): 0: 528: 35.59		Q07931_RABIT (435-647): 8.79e-80: 267: 26.03
+	Mm
		892168 ACTB_MOUSE (1-414): 0: 539: 35.66		MILK2_MOUSE (518-1453): 5.89e-67: 249: 17.00
+	Sp
		142705 ACT_SCHPO (1-414): 0: 529: 33.98		AIN1_SCHPO (507-661): 1.43e-50: 193: 35.67
+	Mm
		930101 ACTH_MOUSE (3-414): 0: 524: 35.59		PLEC_MOUSE (599-2002): 8.98e-28: 125: 12.51
+	Hs
		891887 ACTB_HUMAN (1-414): 0: 539: 35.66		MILK2_HUMAN (1084-1644): 1.03e-13: 79: 17.65
+	Hs
		929869 ACTG_HUMAN (1-414): 0: 538: 35.42		PLEC_HUMAN (619-1989): 3.73e-11: 71.1: 10.87
+	Hs
		932171 ACTC_HUMAN (3-414): 0: 527: 35.59		PLEC_HUMAN (619-1989): 3.73e-11: 71.1: 10.87