Protein: MX1
Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]

Gene: MX1
Organism: Homo sapiens
Interactions: 64
UniProt ID: P20591

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

633357

MX1
Interferon-induced GTP-binding protein Mx1

6

17

Small-scale

0.961

High

633365

SUMO1
Small ubiquitin-related modifier 1

2

3

Small-scale

0.619

High

297749

PIAS2
E3 SUMO-protein ligase PIAS2

2

3

High-throughput

0.606

High

297451

PIAS1
E3 SUMO-protein ligase PIAS1

2

3

Small-scale

0.584

High

633385

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.573

High

633398

DAXX
Death domain-associated protein 6

2

0

Small-scale

0.559

High

633404

BCS1
Mitochondrial chaperone BCS1

2

14

High-throughput

0.558

High

633367

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.552

High

633392

CB39L
Calcium-binding protein 39-like

1

0

High-throughput

0.549

High

633361

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

563178

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

633363

SIK1
Serine/threonine-protein kinase SIK1

1

1

High-throughput

0.536

High

633405

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

633403

TRPC6
Short transient receptor potential channel 6

1

7

Small-scale

0.529

High

425308

ISG15
Ubiquitin-like protein ISG15

1

9

High-throughput

0.515

High

633374

TRPC3
Short transient receptor potential channel 3

1

7

Small-scale

0.515

High

633397

TRPC4
Short transient receptor potential channel 4

1

7

Small-scale

0.515

High

270537

LRP4
Low-density lipoprotein receptor-related protein 4

1

0

High-throughput

0.513

High

633372

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.513

High

633391

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

421484

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

633379

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

129652

CBX4
E3 SUMO-protein ligase CBX4

1

1

Small-scale

0.481

High

222436

PLRG1
Pleiotropic regulator 1

1

3

Small-scale

0.481

High

270998

ZN623
Zinc finger protein 623

1

1

Small-scale

0.481

High

633358

SP100
Nuclear autoantigen Sp-100

1

6

Small-scale

0.481

High

633362

BLM
RecQ-like DNA helicase BLM

1

2

Small-scale

0.481

High

633369

S25A3
Solute carrier family 25 member 3

1

3

Small-scale

0.481

High

633371

ZBT16
Zinc finger and BTB domain-containing protein 16

1

2

Small-scale

0.481

High

633373

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

Small-scale

0.481

High

633378

KI26B
Kinesin-like protein KIF26B

1

5

Small-scale

0.481

High

633383

TBA1A
Tubulin alpha-1A chain

1

2

Small-scale

0.481

High

633394

BRD7
Bromodomain-containing protein 7

1

5

Small-scale

0.481

High

633368

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.480

High

333934

SMC2
Structural maintenance of chromosomes protein 2

1

3

High-throughput

0.479

High

484911

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.479

High

633359

ACVL1
Activin receptor type-1-like

1

1

Small-scale

0.479

High

633360

TRPC1
Short transient receptor potential channel 1

1

7

Small-scale

0.479

High

633376

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.479

High

633386

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

633387

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

633388

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

633393

TRPC7
Short transient receptor potential channel 7

1

7

Small-scale

0.479

High

633401

TRPC5
Short transient receptor potential channel 5

1

7

Small-scale

0.479

High

187460

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

633370

TF65
Transcription factor p65

1

0

Small-scale

0.460

High

633375

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.460

High

633377

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.460

High

633381

ZCH12
Zinc finger CCHC domain-containing protein 12

1

0

Small-scale

0.460

High

633382

KLH35
Kelch-like protein 35

1

0

Small-scale

0.460

High

633384

EPMIP
EPM2A-interacting protein 1

1

0

Small-scale

0.460

High

633390

ZN251
Zinc finger protein 251

1

0

Small-scale

0.460

High

633395

LRC4B
Leucine-rich repeat-containing protein 4B

1

0

Small-scale

0.460

High

633400

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.460

High

633406

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

Small-scale

0.460

High

633366

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.445

High

633396

PSD3
PH and SEC7 domain-containing protein 3

1

1

Small-scale

0.439

High

633399

HMGX4
HMG domain-containing protein 4

1

5

Small-scale

0.439

High

633402

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.426

High

553783

KCRU
Creatine kinase U-type, mitochondrial

1

4

High-throughput

0.407

High

633380

Q68D27
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

633364

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.316

High

633389

CG025
UPF0415 protein C7orf25

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025