HitPredict

Interactor 1: ARP2 (P61160)
Actin-related protein 2 (Actin-like protein 2)
Gene: ACTR2

Interactor 2: ARP5L (Q9BPX5)
Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)
Gene: ARPC5L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	24981860, 26496610, 35271311, 26655834
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~P16-Arc
Common GO terms	GO:0005737 - cytoplasm GO:0005885 - Arp2/3 protein complex GO:0005925 - focal adhesion GO:0034314 - Arp2/3 complex-mediated actin nucleation GO:0051015 - actin filament binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 394 Hs			1 153
+	Hs
		181311 ARP2_HUMAN (1-394): 0: 815: 100.00		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Dm
		800130 ARP2_DROME (1-389): 0: 696: 81.47		Q9VQD8_DROME (1-149): 3.62e-62: 189: 48.67
+	Hs
		891995 ACTB_HUMAN (1-388): 0: 574: 46.65		ARP5L_HUMAN (1-153): 1.54e-71: 213: 100.00
+	Hs
		929987 ACTG_HUMAN (3-388): 0: 573: 46.37		ARP5L_HUMAN (1-153): 1.54e-71: 213: 100.00
+	Hs
		181314 ACTG_HUMAN (3-388): 0: 573: 46.37		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Sc
		689355 ARP2_YEAST (9-390): 0: 549: 67.89		ARPC5_YEAST (6-153): 4.52e-51: 161: 29.03
+	Sp
		1013759 ARP2_SCHPO (9-390): 0: 537: 66.23		ARPC5_SCHPO (10-150): 3.57e-53: 166: 26.67