HitPredict

Interactor 1: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.755

Property	Details
Experiments	26186194, 26976604, 28514442, 31444342, 32047038, 33961781, 11967155, 22013077, 21145461
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 443 Hs			1 745
+	Hs
		897242 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Mm
		897343 CSN2_MOUSE (1-443): 3.15e-127: 377: 100.00		CUL1_MOUSE (6-745): 0: 775: 36.24
+	Hs
		897245 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		897246 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		897244 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	At
		1258869 CSN2_ARATH (12-442): 5.56e-115: 345: 61.20		CUL3A_ARATH (3-745): 0: 788: 30.07
+	Hs
		1024158 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL2_HUMAN (1-745): 0: 840: 100.00
+	Hs
		1041454 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		CUL2_HUMAN (1-745): 0: 840: 100.00
+	At
		1258866 CSN2_ARATH (12-442): 5.56e-115: 345: 61.20		CUL1_ARATH (3-745): 0: 727: 26.53
+	Hs
		1041600 PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		122005 PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1024157 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Hs
		1024160 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1024161 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		1024159 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		87385 C9JFE4_HUMAN (17-443): 1.42e-78: 253: 14.93		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		1041179 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Hs
		897289 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Sp
		142919 CSN2_SCHPO (4-440): 7.31e-88: 276: 45.70		CUL1_SCHPO (1-745): 0: 712: 30.89
+	Hs
		1024200 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		CUL5_HUMAN (7-745): 0: 627: 26.69