HitPredict

Interactor 1: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	27705803, 24981860, 20946988
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:0071339 - MLL1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 160 Hs			1 334
+	Mm
		659344 MAX_MOUSE (1-160): 4.6e-32: 113: 99.38		WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00
+	Hs
		607803 USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		346404 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		379200 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		346159 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49
+	Hs
		209372 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Hs
		209375 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Hs
		245557 MYOD1_HUMAN (11-151): 1.24e-24: 98.4: 16.33		TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32
+	Hs
		346933 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Hs
		379460 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Mm
		1112323 SRBP2_MOUSE (19-149): 2.21e-30: 117: 26.32		FBXW7_MOUSE (198-333): 2.14e-28: 117: 30.15
+	Hs
		898168 MAX_HUMAN (1-160): 2.05e-31: 112: 100.00		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		348035 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54
+	Mm
		1257396 SRBP1_MOUSE (9-134): 2.94e-25: 102: 19.38		FBXW7_MOUSE (198-333): 2.14e-28: 117: 30.15
+	Hs
		738987 SRBP1_HUMAN (9-149): 2.92e-25: 102: 20.00		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Mm
		348444 MYC_MOUSE (19-105): 1.04e-21: 91.9: 37.50		FBXW7_MOUSE (198-333): 2.14e-28: 117: 30.15
+	Hs
		347517 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Dm
		1375911 MYC_DROME (22-118): 9.41e-23: 95.3: 26.53		FBXW7_DROME (40-169): 6.72e-18: 86.7: 39.10
+	Hs
		347550 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		196936 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39