HitPredict

Interactor 1: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	27705803, 29028833, 24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0090575 - RNA polymerase II transcription regulator complex
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 183
+	Hs
		346683 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		379356 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		898100 MAX_HUMAN (1-160): 2.05e-31: 112: 100.00		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		545956 MYOD1_HUMAN (11-151): 1.24e-24: 98.4: 16.33		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		346170 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		379105 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		346518 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		203619 MYOD1_HUMAN (11-151): 1.24e-24: 98.4: 16.33		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		203611 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		348268 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16
+	Hs
		123158 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		347942 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		379890 MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		346802 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00