HitPredict

Interactor 1: FGF12 (P61328)
Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor)
Gene: FGF12

Interactor 2: SCN5A (Q14524)
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)
Gene: SCN5A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	33961781, 22705208
Identification Methods	affinity chromatography technology, pull down, isothermal titration calorimetry, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010765 - positive regulation of sodium ion transport GO:0044325 - transmembrane transporter binding GO:0086002 - cardiac muscle cell action potential involved in contraction GO:1902305 - regulation of sodium ion transmembrane transport
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 243 Hs			1 2016
+	Hs
		1055038 FGF14_HUMAN (1-243): 3.37e-109: 316: 70.97		SCN5A_HUMAN (1-2016): 0: 2020: 100.00
+	Hs
		1055036 FGF13_HUMAN (1-243): 4.47e-105: 305: 65.74		SCN5A_HUMAN (1-2016): 0: 2020: 100.00
+	Hs
		1055037 FGF11_HUMAN (3-223): 3.75e-102: 297: 60.63		SCN5A_HUMAN (1-2016): 0: 2020: 100.00
+	Hs
		723843 FGF12_HUMAN (1-243): 4.79e-120: 343: 100.00		SCN1A_HUMAN (3-2000): 0: 1819: 60.28
+	Hs
		1272762 FGF13_HUMAN (1-243): 4.47e-105: 305: 65.74		SCN2A_HUMAN (3-2000): 0: 1846: 61.21
+	Hs
		1272846 FGF14_HUMAN (1-243): 3.37e-109: 316: 70.97		SCN8A_HUMAN (2-2000): 0: 1730: 59.39