Protein: MKS1
Tectonic-like complex member MKS1 (Meckel syndrome type 1 protein)

Gene: MKS1
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9NXB0

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0003271 - smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1409554

B9D2
B9 domain-containing protein 2

4

7

Small-scale

0.683

High

1435019

TM231
Transmembrane protein 231

3

4

High-throughput

0.656

High

1179151

TECT1
Tectonic-1

2

15

High-throughput

0.628

High

259142

DNJA2
DnaJ homolog subfamily A member 2

2

3

High-throughput

0.611

High

1392484

TECT2
Tectonic-2

2

15

High-throughput

0.611

High

1248845

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

3

1

High-throughput

0.609

High

64911

RCCD1
RCC1 domain-containing protein 1

2

0

High-throughput

0.602

High

192752

ARPC5
Actin-related protein 2/3 complex subunit 5

2

0

High-throughput

0.602

High

1093067

CDC16
Cell division cycle protein 16 homolog

2

0

High-throughput

0.602

High

1333049

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

1352192

SSH3
Protein phosphatase Slingshot homolog 3

2

0

High-throughput

0.602

High

1435653

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

1451931

TRI35
E3 ubiquitin-protein ligase TRIM35

2

0

High-throughput

0.602

High

347371

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.585

High

868781

LEG7
Galectin-7

2

0

High-throughput

0.585

High

1451938

KLK5
Kallikrein-5

2

0

High-throughput

0.585

High

1451930

B9D1
B9 domain-containing protein 1

2

7

High-throughput

0.584

High

516243

PAL4G
Peptidyl-prolyl cis-trans isomerase A-like 4G

2

1

High-throughput

0.552

High

1428561

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.541

High

909399

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

0

Small-scale

0.537

High

1380410

RNF34
E3 ubiquitin-protein ligase RNF34

1

0

Small-scale

0.537

High

777573

K22E
Keratin, type II cytoskeletal 2 epidermal

1

8

High-throughput

0.536

High

1248883

ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

1

1

High-throughput

0.536

High

1249569

TM107
Transmembrane protein 107

1

1

Small-scale

0.515

High

292400

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.513

High

606042

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

642591

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1129280

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.513

High

1178899

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1435927

RDD1
Required for drug-induced death protein 1

1

0

High-throughput

0.513

High

124848

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

610918

TCPA
T-complex protein 1 subunit alpha

1

9

High-throughput

0.479

High

727995

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.479

High

729135

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

Small-scale

0.479

High

765070

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

821600

TCPZ
T-complex protein 1 subunit zeta

1

9

High-throughput

0.479

High

876202

TCPE
T-complex protein 1 subunit epsilon

1

11

High-throughput

0.479

High

882193

TCPG
T-complex protein 1 subunit gamma

1

11

High-throughput

0.479

High

899612

TCPD
T-complex protein 1 subunit delta

1

9

High-throughput

0.479

High

1007311

TCPB
T-complex protein 1 subunit beta

1

11

High-throughput

0.479

High

1038712

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

2

High-throughput

0.479

High

1293176

TMM17
Transmembrane protein 17

1

3

High-throughput

0.479

High

1308598

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1358117

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

1360684

SYNE2
Nesprin-2

1

1

Small-scale

0.479

High

1405882

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1407597

TCPH
T-complex protein 1 subunit eta

1

11

High-throughput

0.479

High

1418743

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.479

High

1431927

PDCL3
Phosducin-like protein 3

1

2

High-throughput

0.479

High

1432939

UN45A
Protein unc-45 homolog A

1

1

High-throughput

0.479

High

1435185

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

1450498

DJC11
DnaJ homolog subfamily C member 11

1

4

High-throughput

0.479

High

1451925

TBA8
Tubulin alpha-8 chain

1

3

High-throughput

0.479

High

1451928

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

5

High-throughput

0.479

High

1451932

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

1

High-throughput

0.479

High

1451935

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

1451937

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.479

High

173457

XPO1
Exportin-1

1

0

High-throughput

0.458

High

176560

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

539429

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

697677

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

725812

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.458

High

829165

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.458

High

921808

COPB
Coatomer subunit beta

1

0

High-throughput

0.458

High

922058

COPA
Coatomer subunit alpha

1

0

High-throughput

0.458

High

935196

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

964074

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.458

High

1045841

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1092673

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1103410

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.458

High

1153935

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1208590

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1240708

CDC73
Parafibromin

1

0

Small-scale

0.458

High

1241126

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

0

High-throughput

0.458

High

1256409

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.458

High

1308107

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.458

High

1371202

GLMN
Glomulin

1

0

High-throughput

0.458

High

1407823

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.458

High

1413080

HAUS8
HAUS augmin-like complex subunit 8

1

0

High-throughput

0.458

High

1428877

EGLN1
Egl nine homolog 1

1

0

High-throughput

0.458

High

1445852

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.458

High

1451288

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1451929

UXT
Protein UXT

1

0

High-throughput

0.458

High

1451933

TBD2B
TBC1 domain family member 2B

1

0

High-throughput

0.458

High

1141442

POSTN
Periostin

1

1

High-throughput

0.437

High

888486

TSP3
Thrombospondin-3

3

0

High-throughput

0.347

High

273789

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

0

High-throughput

0.328

High

1211457

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1381166

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

1279267

R3HCL
Coiled-coil domain-containing protein R3HCC1L

2

0

Small-scale

0.305

High

922399

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.279

Low

1235439

LCN8
Epididymal-specific lipocalin-8

1

0

High-throughput

0.279

Low

1330837

TSYL6
Testis-specific Y-encoded-like protein 6

1

0

High-throughput

0.279

Low

1390362

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1407002

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1451934

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

0

High-throughput

0.279

Low

1314640

M21D2
Nucleotidyltransferase MB21D2

1

0

High-throughput

0.249

Low

1331266

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

1360012

LIPH
Lipase member H

1

0

High-throughput

0.249

Low

1395357

CC136
Coiled-coil domain-containing protein 136

1

0

Small-scale

0.249

Low

1451926

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

0

Small-scale

0.249

Low

1451936

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.249

Low

1081721

YL016
Putative uncharacterized protein LOC100128554

1

0

High-throughput

0.232

Low

1185874

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1253669

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

1451927

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025