HitPredict

Interactor 1: PHS (P61457)
Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)
Gene: PCBD1

Interactor 2: PHS2 (Q9H0N5)
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
Gene: PCBD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	33961781, 20211142
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pterin_4a~Pterin_4a
Common GO terms	GO:0004505 - phenylalanine 4-monooxygenase activity GO:0006729 - tetrahydrobiopterin biosynthetic process GO:0008124 - 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 104 Hs			1 130
+	Mm
		900104 PHS_MOUSE (1-104): 3.02e-50: 155: 99.04		PHS2_MOUSE (13-130): 9.33e-54: 166: 83.05
+	Mm
		900095 PHS_MOUSE (1-104): 3.02e-50: 155: 99.04		PHS_MOUSE (28-130): 3.38e-47: 149: 60.19
+	Hs
		900025 PHS_HUMAN (1-104): 6.3e-50: 154: 100.00		PHS_HUMAN (28-130): 8.31e-47: 148: 61.17
+	Sp
		193888 PHS_SCHPO (8-100): 7.32e-37: 121: 47.31		PHS_SCHPO (35-127): 2.63e-37: 124: 48.39
+	Sc
		753496 PHS_YEAST (7-104): 1.98e-29: 103: 24.55		PHS_YEAST (34-125): 3.98e-27: 99: 23.08