HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0005856 - cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 445
+	Hs
		925258 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		428120 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Bt
		900343 RHOA_BOVIN (1-193): 1.4e-80: 239: 100.00		TBB2B_BOVIN (1-430): 0: 710: 98.14
+	Rn
		1109026 RAC1_RAT (1-193): 8.86e-80: 237: 57.22		TBB2B_RAT (1-430): 0: 710: 98.14
+	Hs
		900852 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		893979 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		428118 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		893889 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		950983 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Hs
		381156 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		TBB4A_HUMAN (1-427): 0: 706: 98.60
+	Hs
		120429 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		TBB2A_HUMAN (1-430): 0: 707: 97.67