HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: AKP13 (Q12802)
A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
Gene: AKAP13

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	19696020, 11696353, 32203420, 31871319, 34591642
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005938 - cell cortex GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 2813
+	Hs
		900612 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGI_HUMAN (1515-2792): 1.63e-103: 368: 31.15
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (1836-2505): 4.28e-98: 353: 19.67
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (1846-2481): 1.75e-96: 337: 22.64
+	Hs
		900663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGJ_HUMAN (1727-2443): 1.34e-89: 313: 15.40
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (1893-2419): 3.08e-85: 295: 17.84
+	Hs
		900948 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG3_HUMAN (1966-2371): 5.78e-84: 289: 17.06
+	Sp
		1000081 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF2_SCHPO (1527-2339): 6.3e-67: 252: 13.50
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (1895-2582): 1.48e-77: 279: 12.70
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (1947-2653): 1.57e-73: 276: 13.52
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (1892-2606): 5.52e-75: 272: 12.36
+	Hs
		900768 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG2_HUMAN (1753-2761): 2e-73: 269: 34.62
+	Hs
		900679 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARG28_HUMAN (1521-2685): 3.39e-71: 268: 30.89
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (1983-2652): 3.75e-68: 258: 14.12
+	Mm
		1146468 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		PKHG5_MOUSE (1974-2347): 2.13e-66: 249: 19.20
+	Hs
		297123 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG5_HUMAN (1974-2344): 1.9e-66: 248: 18.34
+	Sc
		419716 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		ROM2_YEAST (1853-2283): 2.17e-36: 154: 17.37
+	Hs
		900530 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG6_HUMAN (1974-2492): 1.07e-50: 196: 18.38
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (1976-2514): 5.44e-37: 156: 17.57
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (1970-2328): 1.93e-36: 154: 14.32
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (1970-2328): 1.93e-36: 154: 14.32