HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 524
+	Hs
		925245 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		436282 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Mm
		925809 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		PAK2_MOUSE (1-524): 0: 531: 97.14
+	Mm
		103566 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		G5E884_MOUSE (1-523): 2.64e-169: 491: 74.95
+	Hs
		925244 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63
+	Mm
		292048 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35
+	Mm
		292040 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35
+	Hs
		277602 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71
+	Ce
		975572 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		PK1_CAEEL (9-522): 1.29e-137: 411: 52.21
+	Dd
		710121 RACB_DICDI (1-193): 1.37e-85: 252: 54.82		PAKB_DICDI (39-523): 2.76e-123: 383: 35.71
+	Hs
		681775 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83
+	Hs
		568611 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	Hs
		568619 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	Hs
		436148 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	Dd
		710117 RAC1B_DICDI (1-193): 1.45e-77: 231: 53.06		PAKB_DICDI (39-523): 2.76e-123: 383: 35.71
+	Dd
		710122 RACC_DICDI (1-193): 1.55e-77: 231: 52.06		PAKB_DICDI (39-523): 2.76e-123: 383: 35.71
+	Dd
		710120 RACB_DICDI (1-193): 1.37e-85: 252: 54.82		PAKC_DICDI (214-517): 1.68e-89: 284: 49.03
+	Hs
		925692 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PAK5_HUMAN (67-179): 3.87e-12: 70.7: 25.64
+	Hs
		925648 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PAK6_HUMAN (65-127): 1.59e-10: 65.7: 38.10
+	Hs
		330967 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55