HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHG8 (Q7Z628)
Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
Gene: NET1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	9535835, 32203420
Identification Methods	two hybrid, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 596
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (130-505): 8.63e-88: 299: 23.34
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (130-505): 8.63e-88: 299: 23.34
+	Sc
		419716 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		ROM2_YEAST (138-498): 2.4e-77: 269: 20.82
+	Sp
		1000081 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF2_SCHPO (136-515): 2.52e-76: 265: 21.60
+	Hs
		50573 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG3_HUMAN (177-591): 7.46e-88: 297: 22.06
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (127-514): 9.58e-84: 288: 19.37
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (62-591): 1.23e-85: 286: 16.67
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (153-496): 3.48e-81: 281: 21.98
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (129-491): 2.38e-69: 245: 20.80
+	Hs
		900417 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AKP13_HUMAN (7-589): 1.75e-79: 276: 16.48
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (68-595): 1.74e-81: 275: 13.97
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (24-496): 8.06e-81: 273: 18.33
+	Hs
		900690 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		NGEF_HUMAN (4-591): 1.15e-81: 272: 16.43
+	Hs
		900913 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG2_HUMAN (124-584): 2.34e-77: 269: 18.94
+	Hs
		166479 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2L_HUMAN (80-593): 4.08e-77: 267: 17.38
+	Hs
		900679 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARG28_HUMAN (80-567): 5.17e-67: 239: 18.17
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (151-567): 5.08e-60: 219: 17.48
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (156-338): 6.66e-14: 77: 30.26
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (156-329): 2.33e-10: 65.9: 28.18
+	Hs
		900530 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG6_HUMAN (156-443): 1.26e-09: 63.2: 25.46