HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHGP (Q86VW2)
Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)
Gene: ARHGEF25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	15069594, 32203420
Identification Methods	enzymatic study, pull down, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 580
+	Hs
		166479 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2L_HUMAN (76-578): 4.05e-98: 324: 25.34
+	Hs
		500932 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2_HUMAN (101-554): 4.75e-95: 312: 25.75
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (74-563): 1.59e-94: 310: 13.75
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (84-526): 4.03e-89: 295: 18.66
+	Rn
		88818 RAC1_RAT (1-193): 8.86e-80: 237: 57.22		D3ZWV8_RAT (15-579): 2.77e-83: 286: 16.32
+	Hs
		900428 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TIAM1_HUMAN (15-579): 9.35e-83: 284: 16.80
+	Hs
		901037 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV3_HUMAN (70-564): 5.13e-85: 284: 18.02
+	Ce
		975576 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		Q7KPP4_CAEEL (123-509): 1.42e-82: 284: 26.73
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (148-572): 7.05e-82: 282: 31.52
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (118-477): 1.1e-81: 281: 17.78
+	Mm
		925795 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		TIAM1_MOUSE (15-579): 1.49e-81: 281: 16.17
+	Gg
		1141019 Q6LC82_CHICK (1-193): 8.86e-80: 237: 57.22		ARHG6_CHICK (48-578): 2.49e-84: 280: 15.09
+	Hs
		900546 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG4_HUMAN (124-468): 1.3e-80: 277: 29.86
+	Ce
		136793 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		UNC89_CAEEL (131-528): 2.09e-79: 275: 20.20
+	Hs
		50573 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG3_HUMAN (149-467): 1.1e-79: 274: 27.89
+	Hs
		50580 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHG3_HUMAN (149-467): 1.1e-79: 274: 27.89
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (139-469): 2.94e-78: 271: 18.90
+	Hs
		900947 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG4_HUMAN (115-543): 5.7e-79: 264: 19.57
+	Hs
		900913 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG2_HUMAN (164-336): 1.69e-14: 79: 33.89
+	Ce
		975575 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		VAV_CAEEL (130-426): 3.37e-14: 78.2: 25.56