HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHPN2 (Q8IUC4)
Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)
Gene: RHPN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.821

Property	Details
Experiments	12773565, 31871319, 34591642
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HR1~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 686
+	Hs
		900719 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHPN1_HUMAN (23-675): 0: 618: 41.60
+	Hs
		436356 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		BROX_HUMAN (116-523): 2.18e-77: 255: 16.86
+	Hs
		951362 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GOPC_HUMAN (196-600): 7.01e-56: 199: 14.29
+	Hs
		158270 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LIN7A_HUMAN (421-601): 2.76e-30: 121: 14.52
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		167081 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		167063 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		167077 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		900985 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGC_HUMAN (513-600): 1.6e-15: 82.9: 22.73
+	Mm
		925797 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		DLG4_MOUSE (467-663): 9.11e-15: 79.9: 14.83
+	Hs
		436545 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ARHGC_HUMAN (513-600): 1.6e-15: 82.9: 22.73
+	Hs
		900424 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		894523 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ARHGC_HUMAN (513-600): 1.6e-15: 82.9: 22.73
+	Hs
		925239 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		436278 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		950954 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		893948 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		900762 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DLG3_HUMAN (515-636): 2.59e-10: 65.6: 14.18
+	Hs
		545346 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		951207 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		DLG3_HUMAN (515-636): 2.59e-10: 65.6: 14.18