HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 903
+	Hs
		925520 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		436457 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		951237 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		894313 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		545560 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		892540 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125308 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125349 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125100 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125372 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125298 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125135 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125294 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		808080 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		925397 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		925423 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		HACE1_HUMAN (376-897): 4.35e-154: 478: 30.61
+	Hs
		900929 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		900923 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		56825 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Rn
		88544 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		D3ZCF5_RAT (1-535): 3.78e-32: 136: 13.52