HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: SYGP1 (Q96PV0)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: SYNGAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1343
+	Hs
		925530 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SYGP1_HUMAN (1-1343): 0: 1004: 100.00
+	Hs
		436465 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SYGP1_HUMAN (1-1343): 0: 1004: 100.00
+	Hs
		925347 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DAB2P_HUMAN (97-1342): 0: 779: 46.78
+	Hs
		901032 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		NGAP_HUMAN (84-1341): 0: 732: 42.62
+	Hs
		925715 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NGAP_HUMAN (84-1341): 0: 732: 42.62
+	Hs
		436564 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		NGAP_HUMAN (84-1341): 0: 732: 42.62
+	Hs
		925282 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RASA3_HUMAN (157-681): 2.29e-131: 427: 21.64
+	Hs
		809241 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		IQGA1_HUMAN (219-857): 5.95e-123: 421: 13.21
+	Hs
		809255 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		IQGA1_HUMAN (219-857): 5.95e-123: 421: 13.21
+	Mm
		925821 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		IQGA1_MOUSE (219-857): 1.15e-122: 420: 13.49
+	Hs
		436197 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		IQGA1_HUMAN (219-857): 5.95e-123: 421: 13.21
+	Hs
		925259 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		IQGA2_HUMAN (216-848): 1.05e-121: 416: 14.05
+	Hs
		809264 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		IQGA1_HUMAN (219-857): 5.95e-123: 421: 13.21
+	Hs
		900647 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		IQGA3_HUMAN (214-824): 5.56e-119: 409: 12.04
+	Hs
		925404 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		IQGA3_HUMAN (214-824): 5.56e-119: 409: 12.04
+	Hs
		436384 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		IQGA3_HUMAN (214-824): 5.56e-119: 409: 12.04
+	Dd
		710113 RAC1A_DICDI (1-193): 1.77e-77: 231: 54.59		RGAA_DICDI (326-795): 1.55e-92: 319: 13.59
+	Hs
		598453 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		NF1_HUMAN (408-712): 3.21e-82: 301: 23.21
+	Dd
		136239 RAC1A_DICDI (1-193): 1.77e-77: 231: 54.59		GAPA_DICDI (326-726): 3.4e-88: 308: 14.13
+	Hs
		598457 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NF1_HUMAN (408-712): 3.21e-82: 301: 23.21