Protein: EPN4
Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)

Gene: EPN4, CLINT1
Organism: Homo sapiens
Interactions: 226
UniProt ID: Q14677

Gene Ontology (top 5):
GO:0005543 - phospholipid binding
GO:0005654 - nucleoplasm
GO:0005768 - endosome
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1129900

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

4

3

High-throughput

0.896

High

1107538

PICAL
Phosphatidylinositol-binding clathrin assembly protein

3

11

High-throughput

0.871

High

1129906

GGA2
ADP-ribosylation factor-binding protein GGA2

4

7

Small-scale

0.698

High

1083233

AP1B1
AP-1 complex subunit beta-1

4

20

Small-scale

0.696

High

340634

STABP
STAM-binding protein

3

1

High-throughput

0.675

High

940554

AP1S2
AP-1 complex subunit sigma-2

3

5

High-throughput

0.675

High

1129853

STALP
AMSH-like protease

3

1

High-throughput

0.675

High

344689

AP2A1
AP-2 complex subunit alpha-1

3

20

Small-scale

0.670

High

1129844

SMAP2
Stromal membrane-associated protein 2

3

2

High-throughput

0.667

High

1129850

AP2M1
AP-2 complex subunit mu

3

5

High-throughput

0.667

High

135931

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

3

1

High-throughput

0.662

High

1129910

STX8
Syntaxin-8

3

4

High-throughput

0.662

High

483335

CLCB
Clathrin light chain B

3

8

High-throughput

0.656

High

225811

AP1G1
AP-1 complex subunit gamma-1

3

20

Small-scale

0.651

High

988964

AP2B1
AP-2 complex subunit beta

3

20

Small-scale

0.651

High

1026033

CLH1
Clathrin heavy chain 1

3

13

Small-scale

0.651

High

1129803

EPN4
Clathrin interactor 1

1

8

Small-scale

0.647

High

175047

SC16A
Protein transport protein Sec16A

2

6

High-throughput

0.628

High

323715

AP2A2
AP-2 complex subunit alpha-2

2

20

High-throughput

0.628

High

922433

CLH2
Clathrin heavy chain 2

2

13

High-throughput

0.628

High

991531

DYL1
Dynein light chain 1, cytoplasmic

2

5

High-throughput

0.628

High

1129807

RBP1
RalA-binding protein 1

2

4

High-throughput

0.628

High

1129845

STON2
Stonin-2

2

5

High-throughput

0.628

High

1129851

REPS1
RalBP1-associated Eps domain-containing protein 1

2

20

High-throughput

0.628

High

1129867

DNJC7
DnaJ homolog subfamily C member 7

2

6

High-throughput

0.628

High

1129879

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

2

High-throughput

0.628

High

1129905

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

1129893

BMP2K
BMP-2-inducible protein kinase

3

6

Small-scale

0.620

High

483090

CLCA
Clathrin light chain A

2

8

High-throughput

0.611

High

945931

LOXL3
Lysyl oxidase homolog 3

2

2

High-throughput

0.611

High

1129883

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

2

12

Small-scale

0.611

High

1129892

ANLN
Anillin

2

1

High-throughput

0.611

High

278500

VAMP4
Vesicle-associated membrane protein 4

2

0

High-throughput

0.602

High

218183

TGON2
Trans-Golgi network integral membrane protein 2

2

7

High-throughput

0.588

High

1129876

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

12

High-throughput

0.586

High

1129880

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

12

High-throughput

0.586

High

241690

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

588700

RFA2
Replication protein A 32 kDa subunit

2

4

High-throughput

0.584

High

630802

RAB4A
Ras-related protein Rab-4A

2

2

High-throughput

0.584

High

695463

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

768197

RFA3
Replication protein A 14 kDa subunit

2

3

High-throughput

0.584

High

975035

ARF6
ADP-ribosylation factor 6

2

5

High-throughput

0.584

High

976272

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.584

High

1129861

MA7D2
MAP7 domain-containing protein 2

2

8

High-throughput

0.574

High

1129817

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.571

High

269958

AUXI
Auxilin

1

4

High-throughput

0.536

High

396115

ESR1
Estrogen receptor

1

20

High-throughput

0.536

High

563771

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

593999

NCK1
SH2/SH3 adapter protein NCK1

1

10

High-throughput

0.536

High

637517

FLNA
Filamin-A

1

2

High-throughput

0.536

High

650757

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.536

High

698282

MAP4
Microtubule-associated protein 4

1

10

High-throughput

0.536

High

772804

MYH9
Myosin-9

1

1

High-throughput

0.536

High

862844

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.536

High

900814

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.536

High

968298

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.536

High

1113113

CUL3
Cullin-3

1

4

High-throughput

0.536

High

1115653

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

1129812

DREB
Drebrin

1

3

High-throughput

0.536

High

1129822

SCYL2
SCY1-like protein 2

1

2

High-throughput

0.536

High

1129837

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

1129847

MY18A
Unconventional myosin-XVIIIa

1

2

High-throughput

0.536

High

1129848

TFG
Protein TFG

1

6

High-throughput

0.536

High

1129854

DYL2
Dynein light chain 2, cytoplasmic

1

5

High-throughput

0.536

High

1129863

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1129864

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

1129882

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

1

High-throughput

0.536

High

1129902

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.536

High

1129843

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.518

High

216694

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

292630

RENR
Renin receptor

1

0

High-throughput

0.513

High

866685

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

963294

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.513

High

1129825

MBOA1
Membrane-bound glycerophospholipid O-acyltransferase 1

1

0

High-throughput

0.513

High

1129870

OSB10
Oxysterol-binding protein-related protein 10

1

0

High-throughput

0.513

High

1129887

CPNE5
Copine-5

1

0

High-throughput

0.513

High

328012

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

12

High-throughput

0.501

High

429894

JUN
Transcription factor Jun

1

5

Small-scale

0.501

High

839761

EPS15
Epidermal growth factor receptor substrate 15

1

20

Small-scale

0.501

High

952170

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

12

High-throughput

0.501

High

1129872

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

12

High-throughput

0.501

High

556925

MYH7
Myosin-7

1

1

High-throughput

0.489

High

848625

MAGA9
Melanoma-associated antigen 9

1

3

High-throughput

0.489

High

1009758

M3K9
Mitogen-activated protein kinase kinase kinase 9

1

1

High-throughput

0.489

High

1129816

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.489

High

1129858

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1129860

ARX
Homeobox protein ARX

1

9

High-throughput

0.489

High

1129862

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1129874

WNK3
Serine/threonine-protein kinase WNK3

1

1

High-throughput

0.489

High

1129886

PAAT
ATPase PAAT

1

3

High-throughput

0.489

High

1129913

MB212
Protein mab-21-like 2

1

2

High-throughput

0.489

High

1050680

DYN1
Dynamin-1

1

0

Small-scale

0.480

High

126600

RHOD
Rho-related GTP-binding protein RhoD

1

13

High-throughput

0.479

High

170138

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

171704

GAK
Cyclin-G-associated kinase

1

7

High-throughput

0.479

High

172817

XPO1
Exportin-1

1

8

High-throughput

0.479

High

179896

BET1
BET1 homolog

1

4

High-throughput

0.479

High

189567

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

226031

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

247331

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

330969

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.479

High

345822

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

375523

RASK
GTPase KRas

1

10

High-throughput

0.479

High

400838

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411933

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.479

High

425503

ISG15
Ubiquitin-like protein ISG15

1

16

High-throughput

0.479

High

463964

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

529801

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.479

High

540455

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

541489

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

556083

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

562056

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

612224

ARF4
ADP-ribosylation factor 4

1

5

High-throughput

0.479

High

641174

FGFR2
Fibroblast growth factor receptor 2

1

19

High-throughput

0.479

High

642870

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

648512

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

714121

PML
Protein PML

1

7

High-throughput

0.479

High

715586

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

731297

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

827184

ARL1
ADP-ribosylation factor-like protein 1

1

6

High-throughput

0.479

High

862135

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

901811

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

931852

EPHA5
Ephrin type-A receptor 5

1

4

High-throughput

0.479

High

941782

ARL4C
ADP-ribosylation factor-like protein 4C

1

8

High-throughput

0.479

High

944995

RAB25
Ras-related protein Rab-25

1

2

High-throughput

0.479

High

958769

ARF3
ADP-ribosylation factor 3

1

5

High-throughput

0.479

High

970503

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1014894

ARF1
ADP-ribosylation factor 1

1

5

High-throughput

0.479

High

1015018

ARF5
ADP-ribosylation factor 5

1

5

High-throughput

0.479

High

1024576

VIGLN
Vigilin

1

2

High-throughput

0.479

High

1032964

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

1049292

1433F
14-3-3 protein eta

1

11

High-throughput

0.479

High

1067331

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1085550

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

1094542

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.479

High

1096686

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

1107717

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

1129805

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.479

High

1129806

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1129808

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.479

High

1129810

NTRK3
NT-3 growth factor receptor

1

15

High-throughput

0.479

High

1129814

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.479

High

1129819

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1129821

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

4

High-throughput

0.479

High

1129828

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1129830

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1129833

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1129834

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1129835

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.479

High

1129836

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

1129838

ARL14
ADP-ribosylation factor-like protein 14

1

6

High-throughput

0.479

High

1129841

BICD2
Protein bicaudal D homolog 2

1

10

High-throughput

0.479

High

1129849

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.479

High

1129852

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

High-throughput

0.479

High

1129855

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

1129856

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1129857

MYO19
Unconventional myosin-XIX

1

5

High-throughput

0.479

High

1129865

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.479

High

1129869

CP250
Centrosome-associated protein CEP250

1

7

High-throughput

0.479

High

1129871

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.479

High

1129877

WWTR1
WW domain-containing transcription regulator protein 1

1

11

High-throughput

0.479

High

1129881

RAB1B
Ras-related protein Rab-1B

1

1

High-throughput

0.479

High

1129884

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1129896

GTSE1
G2 and S phase-expressed protein 1

1

4

High-throughput

0.479

High

1129899

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1129901

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1129903

UBQL2
Ubiquilin-2

1

9

High-throughput

0.479

High

1129908

MYO6
Unconventional myosin-VI

1

4

Small-scale

0.479

High

1129909

ALK
ALK tyrosine kinase receptor

1

13

High-throughput

0.479

High

1129911

SMAG1
Protein Smaug homolog 1

1

1

High-throughput

0.479

High

1129912

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

1129914

YTHD2
YTH domain-containing family protein 2

1

4

High-throughput

0.479

High

245939

KIF1B
Kinesin-like protein KIF1B

1

3

High-throughput

0.470

High

301425

WFS1
Wolframin

1

1

High-throughput

0.470

High

247908

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

576653

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.458

High

808066

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

867138

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1106866

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1129813

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

1129818

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1129824

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1129846

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1129859

FMNL2
Formin-like protein 2

1

0

High-throughput

0.458

High

1129878

SHRPN
Sharpin

1

0

Small-scale

0.458

High

1129885

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1129890

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1129891

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

1129898

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

85912

B9A025
Lysyl oxidase homolog

1

2

High-throughput

0.445

High

108051

G3V2R1
Sterile alpha motif domain containing 4A

1

1

High-throughput

0.445

High

166300

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

3

High-throughput

0.445

High

537165

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.445

High

765514

BMI1
Polycomb complex protein BMI-1

1

8

High-throughput

0.445

High

848777

MAGAA
Melanoma-associated antigen 10

1

3

High-throughput

0.445

High

1129804

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.445

High

1129820

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.445

High

1129832

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

3

High-throughput

0.445

High

1129840

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

3

High-throughput

0.445

High

1129842

MOT10
Monocarboxylate transporter 10

1

1

High-throughput

0.445

High

1129866

ZBT18
Zinc finger and BTB domain-containing protein 18

1

1

High-throughput

0.445

High

1129875

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1121213

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.437

High

1129826

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1129829

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1129831

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1129873

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.437

High

1129895

ARL15
ADP-ribosylation factor-like protein 15

1

6

High-throughput

0.437

High

1129915

ARL5A
ADP-ribosylation factor-like protein 5A

1

7

High-throughput

0.437

High

1033977

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1129809

CDSN
Corneodesmosin

1

0

High-throughput

0.426

High

1129815

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.426

High

1129823

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

1129827

FBX50
F-box only protein 50

1

0

High-throughput

0.426

High

1129839

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.426

High

1129888

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

1129889

S40A1
Ferroportin

1

0

High-throughput

0.426

High

886860

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

1129897

GGA3
ADP-ribosylation factor-binding protein GGA3

1

8

Small-scale

0.408

High

1129907

GGA1
ADP-ribosylation factor-binding protein GGA1

1

7

Small-scale

0.408

High

1129868

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1129894

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

1129811

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.232

Low

1129904

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.232

Low

1129916

CCD61
Centrosomal protein CCDC61

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025