HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016477 - cell migration GO:0034446 - substrate adhesion-dependent cell spreading GO:0051893 - regulation of focal adhesion assembly
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 1746
+	Hs
		925619 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		436511 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		951343 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		894437 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		545621 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		892599 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		915979 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		120644 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		681775 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568611 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568619 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		436148 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568605 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		900861 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PINK1_HUMAN (1357-1669): 2.87e-73: 258: 23.64
+	Hs
		616691 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Ce
		136793 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		104464 G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		136800 RHO1_CAEEL (1-192): 2.25e-75: 226: 85.94		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		136794 CDC42_CAEEL (1-193): 2.41e-74: 223: 50.78		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80