HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: SEC12 (Q9HCU5)
Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein)
Gene: PREB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 417
+	Hs
		436520 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		951360 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		894462 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		545631 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		120655 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		SEC12_HUMAN (1-417): 1.75e-106: 322: 100.00
+	Hs
		900348 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		WDR5_HUMAN (29-269): 4.37e-37: 139: 9.27
+	Hs
		863392 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		COPA_HUMAN (11-310): 2.64e-37: 146: 12.35
+	Hs
		436239 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		WDR5_HUMAN (29-269): 4.37e-37: 139: 9.27
+	Hs
		436191 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		LIS1_HUMAN (251-411): 1.39e-30: 123: 12.43
+	Mm
		892718 CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33		LIS1_MOUSE (251-411): 1.13e-30: 123: 12.43
+	Hs
		900362 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RACK1_HUMAN (160-364): 7.77e-19: 88.4: 16.02
+	Hs
		152868 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		APAF_HUMAN (139-354): 2.01e-15: 80.7: 19.73