Protein: FLCN
Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein)

Gene: FLCN
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q8NFG4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0004857 - enzyme inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1338821

FNIP1
Folliculin-interacting protein 1

5

2

Small-scale

0.935

High

1338844

FNIP2
Folliculin-interacting protein 2

5

2

Small-scale

0.919

High

1272155

RRAGA
Ras-related GTP-binding protein A

1

3

Small-scale

0.724

High

181008

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

0

High-throughput

0.638

High

1338847

FBW1B
F-box/WD repeat-containing protein 11

3

1

High-throughput

0.633

High

1338827

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

2

3

High-throughput

0.628

High

328075

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

2

Small-scale

0.619

High

1219780

RRAGB
Ras-related GTP-binding protein B

1

3

Small-scale

0.618

High

1338838

RRAGC
Ras-related GTP-binding protein C

1

3

Small-scale

0.618

High

1338841

RRAGD
Ras-related GTP-binding protein D

1

3

Small-scale

0.618

High

1338849

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

2

3

High-throughput

0.611

High

174371

ZN609
Zinc finger protein 609

2

0

High-throughput

0.602

High

451697

PGK2
Phosphoglycerate kinase 2

2

0

High-throughput

0.602

High

596760

DPEP1
Dipeptidase 1

2

0

High-throughput

0.602

High

1316748

WDFY3
WD repeat and FYVE domain-containing protein 3

2

0

High-throughput

0.602

High

1331980

BANP
Protein BANP

2

0

High-throughput

0.602

High

1338825

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

2

0

High-throughput

0.602

High

289362

CTAG2
Cancer/testis antigen 2

2

1

High-throughput

0.601

High

1049581

1433F
14-3-3 protein eta

2

1

High-throughput

0.601

High

279189

ULK1
Serine/threonine-protein kinase ULK1

2

0

Small-scale

0.598

High

901405

RAB7A
Ras-related protein Rab-7a

2

6

Small-scale

0.584

High

421195

ALDOB
Fructose-bisphosphate aldolase B

1

1

High-throughput

0.541

High

461725

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.537

High

930758

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.536

High

1006274

CTG1B
Cancer/testis antigen 1

1

1

High-throughput

0.536

High

1162840

H2A2C
Histone H2A type 2-C

1

1

High-throughput

0.536

High

1307281

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.536

High

482515

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.518

High

1315402

TEFF1
Tomoregulin-1

1

0

High-throughput

0.518

High

1338842

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.518

High

532787

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

1081821

LTOR4
Ragulator complex protein LAMTOR4

1

0

High-throughput

0.513

High

1233365

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.513

High

1324827

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1338832

SEM4C
Semaphorin-4C

1

0

High-throughput

0.513

High

1338835

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.513

High

1338840

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.513

High

1338845

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.513

High

1338851

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.513

High

1338833

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

Small-scale

0.501

High

422650

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

930336

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

Small-scale

0.479

High

170520

RAB7L
Ras-related protein Rab-7L1

1

9

Small-scale

0.479

High

402642

ALDOA
Fructose-bisphosphate aldolase A

1

1

Small-scale

0.479

High

630582

RAB3B
Ras-related protein Rab-3B

1

3

Small-scale

0.479

High

899139

TCPQ
T-complex protein 1 subunit theta

1

2

Small-scale

0.479

High

899486

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.479

High

900932

RAB5C
Ras-related protein Rab-5C

1

1

Small-scale

0.479

High

901953

RAB9A
Ras-related protein Rab-9A

1

5

Small-scale

0.479

High

902210

RAB13
Ras-related protein Rab-13

1

3

Small-scale

0.479

High

955972

RAB8A
Ras-related protein Rab-8A

1

3

Small-scale

0.479

High

956406

RAB2A
Ras-related protein Rab-2A

1

2

Small-scale

0.479

High

956757

RAB10
Ras-related protein Rab-10

1

3

Small-scale

0.479

High

957977

RAB14
Ras-related protein Rab-14

1

2

Small-scale

0.479

High

981321

RAB1A
Ras-related protein Rab-1A

1

2

Small-scale

0.479

High

1007153

TCPB
T-complex protein 1 subunit beta

1

1

Small-scale

0.479

High

1116369

RAB32
Ras-related protein Rab-32

1

8

Small-scale

0.479

High

1145024

RAB35
Ras-related protein Rab-35

1

4

Small-scale

0.479

High

1205001

RABL3
Rab-like protein 3

1

6

Small-scale

0.479

High

1234813

RAB12
Ras-related protein Rab-12

1

4

Small-scale

0.479

High

1307170

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

1

Small-scale

0.479

High

1338824

RAB7B
Ras-related protein Rab-7b

1

7

Small-scale

0.479

High

1338828

TCPH
T-complex protein 1 subunit eta

1

1

Small-scale

0.479

High

1338831

RAB34
Ras-related protein Rab-34

1

5

Small-scale

0.479

High

1338839

RAB18
Ras-related protein Rab-18

1

4

Small-scale

0.479

High

1338848

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

1338850

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.479

High

218500

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

286000

SF3B1
Splicing factor 3B subunit 1

1

0

Small-scale

0.458

High

336993

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

347819

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

404240

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

537547

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

693854

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.458

High

731477

STIP1
Stress-induced-phosphoprotein 1

1

0

Small-scale

0.458

High

916690

PPP5
Serine/threonine-protein phosphatase 5

1

0

Small-scale

0.458

High

996779

TBA1B
Tubulin alpha-1B chain

1

0

Small-scale

0.458

High

1068265

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

1088920

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1113749

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1116678

RIN1
Ras and Rab interactor 1

1

0

Small-scale

0.458

High

1139348

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

Small-scale

0.458

High

1141795

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1144083

TEBP
Prostaglandin E synthase 3

1

0

Small-scale

0.458

High

1147967

SF3B3
Splicing factor 3B subunit 3

1

0

Small-scale

0.458

High

1158439

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

1250819

RFIP1
Rab11 family-interacting protein 1

1

0

Small-scale

0.458

High

1338820

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

Small-scale

0.458

High

1338823

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

1338826

TSN17
Tetraspanin-17

1

0

Small-scale

0.458

High

1338829

MEP50
Methylosome protein WDR77

1

0

Small-scale

0.458

High

1338837

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1338846

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.458

High

95987

E7EUN2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

3

High-throughput

0.445

High

966642

1433G
14-3-3 protein gamma

1

1

High-throughput

0.445

High

1338836

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

76630

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

1338834

RB33B
Ras-related protein Rab-33B

1

4

Small-scale

0.437

High

1258512

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

1338822

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.426

High

1338843

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

1214458

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

0

High-throughput

0.282

High

1338830

HEMGN
Hemogen

1

0

High-throughput

0.282

High

1239099

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025