HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: NECT3 (Q9NQS3)
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Gene: NECTIN3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0043296 - apical junction complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 549
+	Hs
		925647 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NECT3_HUMAN (49-549): 5.39e-105: 327: 100.00
+	Hs
		436527 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		NECT3_HUMAN (49-549): 5.39e-105: 327: 100.00
+	Hs
		951377 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		NECT3_HUMAN (49-549): 5.39e-105: 327: 100.00
+	Hs
		900803 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		KIRR1_HUMAN (41-509): 3.57e-62: 219: 17.59
+	Hs
		925521 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KIRR1_HUMAN (41-509): 3.57e-62: 219: 17.59
+	Hs
		900759 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		436458 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		KIRR1_HUMAN (41-509): 3.57e-62: 219: 17.59
+	Hs
		925492 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		951238 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		KIRR1_HUMAN (41-509): 3.57e-62: 219: 17.59
+	Hs
		894314 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		KIRR1_HUMAN (41-509): 3.57e-62: 219: 17.59
+	Hs
		436439 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		951203 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		894277 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		900635 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SDK1_HUMAN (5-499): 7.02e-34: 139: 13.50
+	Hs
		894276 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		PXDN_HUMAN (246-541): 2.46e-35: 143: 11.26
+	Hs
		901110 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ROBO1_HUMAN (264-548): 5.78e-25: 112: 10.39
+	Hs
		925776 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ROBO1_HUMAN (264-548): 5.78e-25: 112: 10.39
+	Hs
		436602 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ROBO1_HUMAN (264-548): 5.78e-25: 112: 10.39
+	Ce
		136793 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		UNC89_CAEEL (69-289): 2.15e-12: 72.4: 8.60
+	Ce
		104464 G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52		UNC89_CAEEL (69-289): 2.15e-12: 72.4: 8.60