HitPredict

Interactor 1: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Interactor 2: STX5 (Q13190)
Syntaxin-5
Gene: STX5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25910212, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Sec1, Sec1~Syntaxin-5_N
Common GO terms	GO:0000149 - SNARE binding GO:0005829 - cytosol GO:0006886 - intracellular protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 594 Hs			1 355
+	Rn
		901848 STXB1_RAT (1-594): 0: 680: 100.00		STX5_RAT (1-338): 2.72e-112: 332: 94.68
+	Mm
		139528 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1A_MOUSE (58-351): 1.71e-69: 221: 19.80
+	Bt
		699167 STXB1_BOVIN (1-594): 0: 680: 100.00		STX1A_BOVIN (58-351): 1.28e-69: 221: 19.46
+	Rn
		699173 STXB1_RAT (1-594): 0: 680: 100.00		STX1A_RAT (58-351): 2.17e-69: 220: 19.80
+	Mm
		139543 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1B_MOUSE (58-351): 4.62e-69: 219: 19.13
+	Rn
		898824 STXB1_RAT (1-594): 0: 680: 100.00		STX1B_RAT (58-351): 4.62e-69: 219: 19.13
+	Hs
		898829 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1B_HUMAN (58-351): 4.62e-69: 219: 19.13
+	Hs
		901790 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1A_HUMAN (58-351): 1.48e-68: 218: 19.46
+	Hs
		699253 STXB1_HUMAN (1-594): 0: 680: 100.00		STX2_HUMAN (58-354): 3.39e-67: 214: 18.27
+	Rn
		838509 STXB1_RAT (1-594): 0: 680: 100.00		STX2_RAT (58-337): 3.37e-62: 202: 17.96
+	Mm
		192851 STXB2_MOUSE (1-593): 0: 659: 62.80		STX1A_MOUSE (58-351): 1.71e-69: 221: 19.80
+	Hs
		901776 STXB1_HUMAN (1-594): 0: 680: 100.00		STX4_HUMAN (58-354): 9.15e-54: 180: 17.22
+	Hs
		901780 STXB1_HUMAN (1-594): 0: 680: 100.00		STX3_HUMAN (58-335): 8.33e-54: 180: 17.99
+	Mm
		139547 STXB1_MOUSE (1-594): 0: 680: 100.00		STX4_MOUSE (58-354): 3.62e-53: 179: 19.21
+	Rn
		901846 STXB1_RAT (1-594): 0: 680: 100.00		STX3_RAT (58-335): 1.05e-52: 177: 17.63
+	Rn
		901847 STXB1_RAT (1-594): 0: 680: 100.00		STX4_RAT (58-354): 1.28e-52: 177: 19.21
+	Hs
		269405 STXB1_HUMAN (1-594): 0: 680: 100.00		STX11_HUMAN (58-343): 3.52e-50: 171: 14.43
+	Mm
		936823 STXB2_MOUSE (1-593): 0: 659: 62.80		STX4_MOUSE (58-354): 3.62e-53: 179: 19.21
+	Mm
		1145332 STXB2_MOUSE (1-593): 0: 659: 62.80		STX3_MOUSE (58-335): 1.51e-52: 177: 17.63
+	Hs
		269420 STXB2_HUMAN (1-593): 0: 658: 63.47		STX11_HUMAN (58-343): 3.52e-50: 171: 14.43