HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37071664, 37059091
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 1834
+	Hs
		1222545 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		197053 PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Mm
		903669 WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00		KMT2C_MOUSE (886-1764): 1.24e-21: 105: 10.35
+	Hs
		903405 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		152622 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2D_HUMAN (889-1742): 5.87e-09: 63.6: 9.85
+	Hs
		209436 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		152663 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		KMT2D_HUMAN (889-1742): 5.87e-09: 63.6: 9.85
+	Hs
		801423 NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		1281391 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		PRR36_HUMAN (1119-1781): 3.16e-14: 80.9: 8.56
+	Hs
		801299 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		152678 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2D_HUMAN (889-1742): 5.87e-09: 63.6: 9.85
+	Hs
		1056932 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54