HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	26324722, 27563068, 30604749, 24981860, 22665483, 27705803, 33022573, 33472061, 22266653, 17500065
Identification Methods	pull down, affinity chromatography technology, unspecified method, x-ray crystallography, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0042393 - histone binding GO:0042800 - histone H3K4 methyltransferase activity and 1 others more... GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Hs			1 4911
+	Mm
		903669 WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00		KMT2C_MOUSE (1-4911): 0: 2324: 84.57
+	Hs
		165657 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		209441 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		903234 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		903149 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Dm
		1129076 WDS_DROME (3-290): 7.53e-92: 279: 31.21		SET1_DROME (4698-4911): 6.13e-60: 232: 34.57
+	Hs
		903609 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	At
		1319861 WDR5A_ARATH (2-241): 2.46e-75: 236: 27.82		ATX1_ARATH (4688-4911): 9.07e-68: 254: 31.58
+	Hs
		203735 DAW1_HUMAN (144-333): 8.06e-44: 157: 30.69		SUV91_HUMAN (4579-4910): 8.61e-90: 302: 19.18
+	Hs
		903604 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152622 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Sc
		744551 SWD3_YEAST (29-330): 8.4e-45: 157: 34.47		SET1_YEAST (4555-4911): 4.81e-78: 286: 25.80
+	Hs
		1080207 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		331862 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		209466 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		1059779 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		1018714 NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		152663 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		975303 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		152678 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82