HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	36395886, 32350066
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 707
+	Hs
		1103007 SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Dm
		1358859 WDS_DROME (3-290): 7.53e-92: 279: 31.21		FBXW7_DROME (142-705): 3.41e-131: 421: 66.33
+	Hs
		1281292 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (457-706): 3e-66: 226: 27.08
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (570-706): 6.06e-25: 108: 23.74
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (269-366): 5.18e-09: 61.2: 13.86
+	Hs
		245633 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (570-706): 5.69e-27: 115: 23.02
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (459-659): 7.29e-18: 88.6: 27.96
+	Sc
		630844 NLE1_YEAST (167-333): 3.95e-41: 152: 23.70		NLE1_YEAST (537-705): 1.06e-34: 140: 23.50
+	Sp
		999838 TUP11_SCHPO (3-117): 1.07e-31: 126: 25.19		TUP11_SCHPO (604-706): 2.18e-10: 65.8: 15.39
+	Hs
		1346954 NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54		NLE1_HUMAN (269-366): 5.18e-09: 61.2: 13.86
+	Sp
		999842 TUP12_SCHPO (2-118): 1.15e-30: 123: 20.30		TUP11_SCHPO (604-706): 2.18e-10: 65.8: 15.39