Protein: MCPH1
Microcephalin

Gene: MCPH1
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q8NEM0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000132 - establishment of mitotic spindle orientation
GO:0000278 - mitotic cell cycle
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1029116

E2F1
Transcription factor E2F1

3

1

Small-scale

0.678

High

1337542

EFC4B
EF-hand calcium-binding domain-containing protein 4B

3

0

High-throughput

0.634

High

1337527

MCPH1
Microcephalin

1

0

Small-scale

0.631

High

799308

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.618

High

1337531

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.618

High

1055944

RAD51
DNA repair protein RAD51 homolog 1

2

1

Small-scale

0.595

High

591741

H2AX
Histone H2AX

2

0

Small-scale

0.569

High

1149938

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.561

High

1337529

SMRC2
SWI/SNF complex subunit SMARCC2

1

2

Small-scale

0.561

High

1337547

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

2

0

Small-scale

0.559

High

283509

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.541

High

564082

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

1086638

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.537

High

1337554

FBW1B
F-box/WD repeat-containing protein 11

1

0

Small-scale

0.529

High

718596

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.513

High

246775

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.508

High

888196

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.501

High

1102210

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.501

High

1109474

ATR
Serine/threonine-protein kinase ATR

1

1

Small-scale

0.501

High

1128181

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

1

1

Small-scale

0.501

High

706228

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

755986

MCM5
DNA replication licensing factor MCM5

1

1

Small-scale

0.481

High

1337548

SMOX
Spermine oxidase

1

1

Small-scale

0.481

High

163140

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

1337549

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.479

High

903202

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

2

Small-scale

0.479

High

903418

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

2

Small-scale

0.479

High

1124150

E2F2
Transcription factor E2F2

1

1

Small-scale

0.479

High

1337533

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

Small-scale

0.479

High

143746

WN10B
Protein Wnt-10b

1

0

Small-scale

0.460

High

217274

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

Small-scale

0.460

High

272326

OBSL1
Obscurin-like protein 1

1

0

Small-scale

0.460

High

391704

MT2
Metallothionein-2

1

0

Small-scale

0.460

High

445976

ENOA
Alpha-enolase

1

0

Small-scale

0.460

High

474836

VIME
Vimentin

1

0

Small-scale

0.460

High

522828

COT1
COUP transcription factor 1

1

0

Small-scale

0.460

High

532785

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.460

High

567450

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

609751

LEG3
Galectin-3

1

0

Small-scale

0.460

High

637640

FLNA
Filamin-A

1

0

Small-scale

0.460

High

650860

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

Small-scale

0.460

High

702998

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.460

High

876074

TCPE
T-complex protein 1 subunit epsilon

1

0

Small-scale

0.460

High

952251

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

Small-scale

0.460

High

976116

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.460

High

992865

RACK1
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.460

High

993249

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.460

High

1090469

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

Small-scale

0.460

High

1101229

NMI
N-myc-interactor

1

0

Small-scale

0.460

High

1127015

RBM39
RNA-binding protein 39

1

0

Small-scale

0.460

High

1143960

IPYR
Inorganic pyrophosphatase

1

0

Small-scale

0.460

High

1218538

PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

1

0

Small-scale

0.460

High

1242437

WDR73
Integrator complex assembly factor WDR73

1

0

Small-scale

0.460

High

1256961

FBX50
F-box only protein 50

1

0

Small-scale

0.460

High

1270306

SPT6H
Transcription elongation factor SPT6

1

0

Small-scale

0.460

High

1280118

SEN54
tRNA-splicing endonuclease subunit Sen54

1

0

Small-scale

0.460

High

1309689

WDR75
WD repeat-containing protein 75

1

0

Small-scale

0.460

High

1337528

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

0

Small-scale

0.460

High

1337534

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

Small-scale

0.460

High

1337535

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.460

High

1337537

THA11
THAP domain-containing protein 11

1

0

Small-scale

0.460

High

1337538

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

Small-scale

0.460

High

1337541

CCD77
Coiled-coil domain-containing protein 77

1

0

Small-scale

0.460

High

1337543

SKI8
Superkiller complex protein 8

1

0

Small-scale

0.460

High

1337544

RM46
Large ribosomal subunit protein mL46

1

0

Small-scale

0.460

High

1337545

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

Small-scale

0.460

High

1337546

AKIP1
A-kinase-interacting protein 1

1

0

Small-scale

0.460

High

1337550

UXT
Protein UXT

1

0

Small-scale

0.460

High

1337552

RLP24
Probable ribosome biogenesis protein RLP24

1

0

Small-scale

0.460

High

1337553

PHF11
PHD finger protein 11

1

0

High-throughput

0.460

High

1337556

CSN3
COP9 signalosome complex subunit 3

1

0

Small-scale

0.460

High

1337557

RUVB2
RuvB-like 2

1

0

Small-scale

0.460

High

535308

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

828226

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.458

High

897344

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

904344

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

980012

H4
Histone H4

1

0

High-throughput

0.458

High

991069

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

1045540

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1132839

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

Small-scale

0.458

High

1220665

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1337551

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1337555

FZR1
Fizzy-related protein homolog

1

0

Small-scale

0.458

High

384180

CO1A1
Collagen alpha-1(I) chain

1

1

Small-scale

0.439

High

1279434

WDR53
WD repeat-containing protein 53

1

1

Small-scale

0.439

High

1316146

CORA1

1

1

Small-scale

0.439

High

1337539

S10AG
Protein S100-A16

1

1

Small-scale

0.439

High

1198602

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

131473

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.251

Low

219202

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.251

Low

459315

CATL1
Procathepsin L

1

0

Small-scale

0.251

Low

654539

FBLN1
Fibulin-1

1

0

Small-scale

0.251

Low

773571

COPB2
Coatomer subunit beta'

1

0

Small-scale

0.251

Low

1124275

IF4A2
Eukaryotic initiation factor 4A-II

1

0

Small-scale

0.251

Low

1142996

PMVK
Phosphomevalonate kinase

1

0

Small-scale

0.251

Low

1337530

MITD1
MIT domain-containing protein 1

1

0

Small-scale

0.251

Low

1337532

MRP2
ATP-binding cassette sub-family C member 2

1

0

High-throughput

0.251

Low

1337536

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

Small-scale

0.251

Low

1337540

B3GT6
Beta-1,3-galactosyltransferase 6

1

0

Small-scale

0.251

Low

1141792

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

230199

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025