HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	33961781, 36931259, 28514442, 32814053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 594
+	Hs
		909517 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		981977 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		927005 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		904759 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		RAPH1_HUMAN (34-484): 6.16e-107: 350: 23.94
+	Hs
		927204 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		RAPH1_HUMAN (34-484): 6.16e-107: 350: 23.94
+	Hs
		909481 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ITK_HUMAN (293-589): 1.9e-60: 213: 15.47
+	Hs
		411661 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		788960 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Hs
		782766 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		782764 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		411666 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		909427 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		904426 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924498 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Gg
		94492 1433E_CHICK (1-244): 2.02e-141: 398: 63.53		KSYK_CHICK (485-591): 1.81e-12: 72.1: 26.17
+	Hs
		683181 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		782768 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		683253 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924450 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Gg
		94476 1433Z_CHICK (2-245): 4.61e-108: 313: 74.59		KSYK_CHICK (485-591): 1.81e-12: 72.1: 26.17