HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: PPR27 (Q86WC6)
Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin)
Gene: PPP1R27

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.50	0.613

Property	Details
Experiments	32296183, unassigned1304, 19389623
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, far western blotting, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 154
+	Hs
		905838 PP1A_HUMAN (1-330): 0: 614: 100.00		ANK2_HUMAN (5-153): 4.91e-36: 133: 13.58
+	Hs
		905849 PP1A_HUMAN (1-330): 0: 614: 100.00		Q05BL1_HUMAN (2-139): 3.81e-36: 133: 28.08
+	Hs
		905884 PP1A_HUMAN (1-330): 0: 614: 100.00		ASPP2_HUMAN (2-154): 2.9e-36: 133: 26.22
+	Mm
		93784 PP1A_MOUSE (1-330): 0: 614: 99.70		E9QJU8_MOUSE (2-139): 5.24e-36: 133: 28.08
+	Hs
		906081 PP1A_HUMAN (1-330): 0: 614: 100.00		ASPP1_HUMAN (2-139): 1.61e-34: 128: 26.62
+	Mm
		906278 PP1A_MOUSE (1-330): 0: 614: 99.70		ASPP1_MOUSE (2-139): 3.26e-34: 128: 27.34
+	Hs
		225132 PP1A_HUMAN (1-330): 0: 614: 100.00		MYPT2_HUMAN (5-152): 7.88e-29: 112: 19.66
+	Mm
		906293 PP1A_MOUSE (1-330): 0: 614: 99.70		MYPT2_MOUSE (5-152): 4.86e-28: 110: 19.10
+	Hs
		161347 PP1A_HUMAN (1-330): 0: 614: 100.00		MYPT1_HUMAN (7-148): 2.61e-26: 105: 13.73
+	Mm
		906366 PP1A_MOUSE (1-330): 0: 614: 99.70		MYPT1_MOUSE (7-148): 3.81e-26: 104: 13.73
+	Hs
		737760 PP1G_HUMAN (1-330): 0: 579: 90.66		Q05BL1_HUMAN (2-139): 3.81e-36: 133: 28.08
+	Hs
		737795 PP1G_HUMAN (1-330): 0: 579: 90.66		ASPP2_HUMAN (2-154): 2.9e-36: 133: 26.22
+	Hs
		906146 PP1A_HUMAN (1-330): 0: 614: 100.00		TANC2_HUMAN (10-153): 1.11e-21: 92: 14.14
+	Mm
		906252 PP1A_MOUSE (1-330): 0: 614: 99.70		PP12C_MOUSE (35-148): 1.65e-20: 88.8: 32.20
+	Hs
		906116 PP1A_HUMAN (1-330): 0: 614: 100.00		PP12C_HUMAN (35-138): 1.64e-18: 83.1: 32.41
+	Hs
		225129 PP1G_HUMAN (1-330): 0: 579: 90.66		MYPT2_HUMAN (5-152): 7.88e-29: 112: 19.66
+	Hs
		161322 PP1G_HUMAN (1-330): 0: 579: 90.66		MYPT1_HUMAN (7-148): 2.61e-26: 105: 13.73
+	Mm
		926555 PP1G_MOUSE (1-330): 0: 579: 90.66		MYPT1_MOUSE (7-148): 3.81e-26: 104: 13.73
+	Hs
		906079 PP1A_HUMAN (1-330): 0: 614: 100.00		PP16A_HUMAN (17-118): 1.42e-13: 68.8: 22.55
+	Hs
		906099 PP1A_HUMAN (1-330): 0: 614: 100.00		PP16B_HUMAN (31-95): 1.69e-11: 62.8: 20.00