Protein: KAD4
Adenylate kinase 4, mitochondrial (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)

Gene: KAD4, AK4
Organism: Homo sapiens
Interactions: 153
UniProt ID: P27144

Gene Ontology (top 5):
GO:0002082 - regulation of oxidative phosphorylation
GO:0004017 - AMP kinase activity
GO:0004550 - nucleoside diphosphate kinase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690501

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

690467

IF2M
Translation initiation factor IF-2, mitochondrial

2

1

High-throughput

0.611

High

690553

MTG2
Mitochondrial ribosome-associated GTPase 2

2

1

High-throughput

0.611

High

562870

CCL5
C-C motif chemokine 5

2

0

High-throughput

0.602

High

653140

HEMH
Ferrochelatase, mitochondrial

2

2

High-throughput

0.601

High

61430

VWA8
von Willebrand factor A domain-containing protein 8

2

0

High-throughput

0.585

High

690522

SERB1
SERPINE1 mRNA-binding protein 1

2

0

High-throughput

0.585

High

279658

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

690566

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.576

High

690459

T2EB
Transcription initiation factor IIE subunit beta

2

1

High-throughput

0.574

High

690524

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

166621

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.536

High

296095

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

1

High-throughput

0.536

High

322203

GLSK
Glutaminase kidney isoform, mitochondrial

1

2

High-throughput

0.536

High

425772

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

1

High-throughput

0.536

High

484389

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

547093

PYC
Pyruvate carboxylase, mitochondrial

1

1

High-throughput

0.536

High

554778

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

6

High-throughput

0.536

High

690461

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

690462

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

High-throughput

0.536

High

690492

SYLM
Leucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

690497

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

1

High-throughput

0.536

High

690498

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.536

High

690500

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

4

High-throughput

0.536

High

690507

SYVM
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

690510

ACD10
Acyl-CoA dehydrogenase family member 10

1

1

High-throughput

0.536

High

690515

SYPM
Probable proline--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

690526

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

1

High-throughput

0.536

High

690528

NSUN4
5-cytosine rRNA methyltransferase NSUN4

1

1

High-throughput

0.536

High

690529

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

690531

ECHD3
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial

1

1

High-throughput

0.536

High

690546

SYTM
Threonine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

690558

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

1

High-throughput

0.536

High

690564

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

1

High-throughput

0.536

High

690460

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.518

High

66133

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.513

High

134244

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

177516

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

271019

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

425878

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

611769

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

643221

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.513

High

662769

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

690470

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.513

High

690472

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

690473

FGF12
Fibroblast growth factor 12

1

0

High-throughput

0.513

High

690483

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.513

High

690502

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.513

High

690511

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.513

High

690512

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

690517

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.513

High

690530

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

690533

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.513

High

690535

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.513

High

690539

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.513

High

690540

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

690559

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.513

High

690571

SARDH
Sarcosine dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

690575

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

0

High-throughput

0.513

High

690576

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

690577

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.513

High

690578

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

421536

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

690471

CNN1
Calponin-1

1

1

High-throughput

0.489

High

690476

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

1

High-throughput

0.489

High

690479

CAV1
Caveolin-1

1

2

High-throughput

0.489

High

690508

SYT6
Synaptotagmin-6

1

1

High-throughput

0.489

High

690513

T184A
Transmembrane protein 184A

1

1

High-throughput

0.489

High

690523

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

High-throughput

0.489

High

690579

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

690490

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.486

High

281888

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287241

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

362806

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

400311

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

470860

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.479

High

532377

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

690463

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

690464

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

690466

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

690474

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

690484

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

690485

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

690486

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

690488

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

690489

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

690493

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.479

High

690495

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

690503

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

690505

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

1

Small-scale

0.479

High

690509

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

690514

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

690516

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

4

High-throughput

0.479

High

690518

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

690527

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.479

High

690538

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

690545

TR61B
tRNA

1

1

High-throughput

0.479

High

690552

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

690554

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

690557

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

690563

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

690567

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

4

High-throughput

0.479

High

690569

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

690570

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

350793

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

519052

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

690465

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

690469

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

690475

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

690481

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

690482

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

690491

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

690532

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

690542

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

690543

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

690544

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

690547

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

690549

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

690550

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

690551

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

690556

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

690565

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

690568

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

598692

ANFB
Natriuretic peptides B

1

1

High-throughput

0.445

High

690477

E2F1
Transcription factor E2F1

1

1

High-throughput

0.445

High

690478

TAGL
Transgelin

1

1

High-throughput

0.445

High

690487

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.445

High

690506

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

690534

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

690560

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

690562

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

690572

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

690573

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

690504

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

1

High-throughput

0.437

High

690496

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.426

High

690519

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

330048

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

690520

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

690541

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

3

0

High-throughput

0.347

High

690536

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.282

High

345153

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

690468

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.279

Low

690480

COAA1

1

0

High-throughput

0.279

Low

690499

UNC50
Protein unc-50 homolog

1

0

High-throughput

0.279

Low

690521

NIPA2
Magnesium transporter NIPA2

1

0

High-throughput

0.279

Low

690525

AP2B
Transcription factor AP-2-beta

1

0

High-throughput

0.279

Low

690537

FMNL2
Formin-like protein 2

1

0

High-throughput

0.279

Low

690548

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

690555

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

690561

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

690574

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

690494

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.269

Low

210242

PHF1
PHD finger protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025