HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: PP12C (Q9BZL4)
Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)
Gene: PPP1R12C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29669786, 25593058
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 782
+	Hs
		738024 PP1G_HUMAN (1-330): 0: 579: 90.66		PP12C_HUMAN (1-782): 1.36e-154: 471: 100.00
+	Mm
		906252 PP1A_MOUSE (1-330): 0: 614: 99.70		PP12C_MOUSE (19-782): 1.24e-138: 429: 85.92
+	Hs
		906079 PP1A_HUMAN (1-330): 0: 614: 100.00		PP16A_HUMAN (13-478): 5.8e-85: 281: 29.56
+	Hs
		906146 PP1A_HUMAN (1-330): 0: 614: 100.00		TANC2_HUMAN (4-720): 4.19e-69: 250: 16.47
+	Hs
		737978 PP1G_HUMAN (1-330): 0: 579: 90.66		PP16A_HUMAN (13-478): 5.8e-85: 281: 29.56
+	Hs
		906099 PP1A_HUMAN (1-330): 0: 614: 100.00		PP16B_HUMAN (12-545): 6.28e-69: 239: 23.19
+	Hs
		738057 PP1G_HUMAN (1-330): 0: 579: 90.66		TANC2_HUMAN (4-720): 4.19e-69: 250: 16.47
+	Hs
		737999 PP1G_HUMAN (1-330): 0: 579: 90.66		PP16B_HUMAN (12-545): 6.28e-69: 239: 23.19
+	Mm
		906293 PP1A_MOUSE (1-330): 0: 614: 99.70		MYPT2_MOUSE (298-782): 1.34e-28: 125: 23.16
+	Hs
		225132 PP1A_HUMAN (1-330): 0: 614: 100.00		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		905838 PP1A_HUMAN (1-330): 0: 614: 100.00		ANK2_HUMAN (192-510): 1.07e-25: 116: 13.86
+	Hs
		3260 PP1B_HUMAN (1-330): 0: 568: 87.88		A0A0S2Z4Q8_HUMAN (12-191): 1.32e-41: 152: 49.74
+	Hs
		161347 PP1A_HUMAN (1-330): 0: 614: 100.00		MYPT1_HUMAN (542-782): 1.47e-22: 105: 33.61
+	Mm
		906366 PP1A_MOUSE (1-330): 0: 614: 99.70		MYPT1_MOUSE (542-782): 3.39e-21: 101: 32.78
+	Hs
		225129 PP1G_HUMAN (1-330): 0: 579: 90.66		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		161322 PP1G_HUMAN (1-330): 0: 579: 90.66		MYPT1_HUMAN (542-782): 1.47e-22: 105: 33.61
+	Gg
		907234 PP1B_CHICK (1-330): 0: 568: 87.88		MYPT1_CHICK (10-232): 1.66e-24: 112: 16.54
+	Mm
		926555 PP1G_MOUSE (1-330): 0: 579: 90.66		MYPT1_MOUSE (542-782): 3.39e-21: 101: 32.78
+	Hs
		737925 PP1G_HUMAN (1-330): 0: 579: 90.66		ANR42_HUMAN (187-357): 5.42e-22: 100: 20.00
+	Hs
		906000 PP1A_HUMAN (1-330): 0: 614: 100.00		PPR27_HUMAN (223-309): 1.62e-09: 59.3: 40.23