Protein: AL1B1
Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)

Gene: AL1B1, ALDH1B1
Organism: Homo sapiens
Interactions: 126
UniProt ID: P30837

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423881

ALDH2
Aldehyde dehydrogenase, mitochondrial

2

15

High-throughput

0.789

High

722763

FEM1B
Protein fem-1 homolog B

3

2

High-throughput

0.667

High

371270

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.656

High

722742

DHRS4
Dehydrogenase/reductase SDR family member 4

3

0

High-throughput

0.638

High

722764

SUFU
Suppressor of fused homolog

3

0

High-throughput

0.638

High

722707

CUL3
Cullin-3

2

3

High-throughput

0.611

High

240857

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

722747

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

3

Small-scale

0.584

High

277895

SH3L1
Adapter SH3BGRL

2

2

High-throughput

0.571

High

622413

ELK1
ETS domain-containing protein Elk-1

2

1

High-throughput

0.571

High

722703

MK07
Mitogen-activated protein kinase 7

2

3

High-throughput

0.571

High

551728

FABPI
Fatty acid-binding protein, intestinal

1

1

High-throughput

0.541

High

213832

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

634318

LMNB1
Lamin-B1

1

3

High-throughput

0.536

High

720952

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.536

High

722700

CALD1
Caldesmon

1

1

High-throughput

0.536

High

722706

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.536

High

722712

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

541849

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.515

High

722745

PITM3
Membrane-associated phosphatidylinositol transfer protein 3

1

1

High-throughput

0.515

High

209485

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.513

High

369020

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

563275

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

722683

MYH9
Myosin-9

1

0

High-throughput

0.513

High

722718

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

722767

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

185456

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

722698

EXOSX
Exosome complex component 10

1

2

High-throughput

0.481

High

722750

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.481

High

279668

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

332083

MRP6
ATP-binding cassette sub-family C member 6

1

1

Small-scale

0.479

High

403857

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

411434

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

470872

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

507576

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

532393

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

583820

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.479

High

722682

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

722684

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

722685

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.479

High

722687

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

722688

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

722689

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

2

High-throughput

0.479

High

722691

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

722692

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

722693

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

722694

RHOB
Rho-related GTP-binding protein RhoB

1

3

High-throughput

0.479

High

722695

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

722696

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

722701

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

722702

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

722704

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

722705

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

722709

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

722710

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

722714

FSCN1
Fascin

1

1

High-throughput

0.479

High

722715

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.479

High

722716

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

722717

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.479

High

722719

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

722724

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

722730

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

722732

RN128
E3 ubiquitin-protein ligase RNF128

1

2

High-throughput

0.479

High

722736

MFRN2
Mitoferrin-2

1

1

High-throughput

0.479

High

722737

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

722743

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

722752

MTG2
Mitochondrial ribosome-associated GTPase 2

1

5

High-throughput

0.479

High

722755

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

722756

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

722757

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

722759

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

722761

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

722766

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

289934

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

315176

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

324575

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

330689

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

519056

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

606297

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

722686

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

722699

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

722713

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

722725

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

722739

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

722749

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

722754

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

722758

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

722762

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.458

High

429372

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

529176

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

538731

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

5

High-throughput

0.445

High

653152

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

722690

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

722708

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.445

High

722721

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

722722

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

722746

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

722748

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

High-throughput

0.445

High

722751

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

5

High-throughput

0.445

High

293263

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

722720

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

2

High-throughput

0.437

High

722727

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

722728

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

722733

RN139
E3 ubiquitin-protein ligase RNF139

1

1

High-throughput

0.437

High

722734

SCTM1
Secreted and transmembrane protein 1

1

1

High-throughput

0.437

High

722735

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

2

High-throughput

0.437

High

722738

FAF2
FAS-associated factor 2

1

1

High-throughput

0.437

High

722753

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

722760

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.437

High

939

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

117050

J3KSN0
Protein K-12

1

1

High-throughput

0.407

High

722768

X6RFA8
Solute carrier family 25 member 28

1

2

High-throughput

0.407

High

184126

RER1
Protein RER1

1

0

High-throughput

0.279

Low

389075

FINC
Fibronectin

1

0

High-throughput

0.279

Low

722711

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.279

Low

722723

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

722729

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

67004

CO6A6

1

0

High-throughput

0.269

Low

722741

CHOLN
Protein cholesin

1

0

High-throughput

0.269

Low

722744

ZN341
Zinc finger protein 341

1

0

High-throughput

0.269

Low

208467

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.249

Low

722697

NDP
Norrin

1

0

Small-scale

0.249

Low

722726

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

722731

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

722740

PCFT
Proton-coupled folate transporter

1

0

High-throughput

0.232

Low

722765

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025