HitPredict

Interactor 1: PP1A (P62137)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: Ppp1ca

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, PDZ~STPPase_N
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0043197 - dendritic spine GO:0044877 - protein-containing complex binding GO:0098794 - postsynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 330 Mm			1 724
+	Mm
		906652 PP1B_MOUSE (1-330): 0: 568: 87.58		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		906059 PP1A_HUMAN (1-330): 0: 614: 99.70		DLG3_HUMAN (28-724): 0: 600: 64.92
+	Mm
		926531 PP1G_MOUSE (1-330): 0: 579: 90.36		DLG3_MOUSE (20-724): 0: 585: 63.94
+	Mm
		915328 PP2AB_MOUSE (8-302): 1.41e-176: 492: 48.31		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		737775 PP1G_HUMAN (1-330): 0: 579: 90.36		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		905890 PP1A_HUMAN (1-330): 0: 614: 99.70		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		905921 PP1A_HUMAN (1-330): 0: 614: 99.70		DLG2_HUMAN (234-580): 8.36e-18: 90.1: 19.55
+	Hs
		737799 PP1G_HUMAN (1-330): 0: 579: 90.36		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		906454 PP1B_HUMAN (1-330): 0: 568: 87.58		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		159165 PP1G_HUMAN (1-330): 0: 579: 90.36		CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43