HitPredict

Interactor 1: PP1A (P62137)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: Ppp1ca

Interactor 2: MYPT2 (Q8BG95)
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Gene: Ppp1r12b

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29669786, 25593058
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Mm			1 976
+	Hs
		225132 PP1A_HUMAN (1-330): 0: 614: 99.70		MYPT2_HUMAN (1-976): 3.15e-137: 438: 89.10
+	Hs
		225129 PP1G_HUMAN (1-330): 0: 579: 90.36		MYPT2_HUMAN (1-976): 3.15e-137: 438: 89.10
+	Hs
		225133 PP1B_HUMAN (1-330): 0: 568: 87.58		MYPT2_HUMAN (1-976): 3.15e-137: 438: 89.10
+	Hs
		161347 PP1A_HUMAN (1-330): 0: 614: 99.70		MYPT1_HUMAN (17-976): 3.27e-100: 339: 44.52
+	Mm
		906366 PP1A_MOUSE (1-330): 0: 614: 100.00		MYPT1_MOUSE (17-976): 6.12e-93: 319: 43.59
+	Hs
		161322 PP1G_HUMAN (1-330): 0: 579: 90.36		MYPT1_HUMAN (17-976): 3.27e-100: 339: 44.52
+	Hs
		161348 PP1B_HUMAN (1-330): 0: 568: 87.58		MYPT1_HUMAN (17-976): 3.27e-100: 339: 44.52
+	Mm
		926555 PP1G_MOUSE (1-330): 0: 579: 90.36		MYPT1_MOUSE (17-976): 6.12e-93: 319: 43.59
+	Hs
		906079 PP1A_HUMAN (1-330): 0: 614: 99.70		PP16A_HUMAN (1-414): 1.42e-83: 281: 29.86
+	Hs
		906005 PP1A_HUMAN (1-330): 0: 614: 99.70		MIB1_HUMAN (2-396): 7.48e-70: 253: 19.28
+	Hs
		737978 PP1G_HUMAN (1-330): 0: 579: 90.36		PP16A_HUMAN (1-414): 1.42e-83: 281: 29.86
+	Hs
		906099 PP1A_HUMAN (1-330): 0: 614: 99.70		PP16B_HUMAN (10-506): 7.54e-69: 242: 27.10
+	Hs
		906116 PP1A_HUMAN (1-330): 0: 614: 99.70		PP12C_HUMAN (527-976): 2.8e-62: 228: 24.16
+	Mm
		906252 PP1A_MOUSE (1-330): 0: 614: 100.00		PP12C_MOUSE (588-976): 2.04e-60: 222: 26.65
+	Hs
		737999 PP1G_HUMAN (1-330): 0: 579: 90.36		PP16B_HUMAN (10-506): 7.54e-69: 242: 27.10
+	Hs
		738024 PP1G_HUMAN (1-330): 0: 579: 90.36		PP12C_HUMAN (527-976): 2.8e-62: 228: 24.16
+	Hs
		906000 PP1A_HUMAN (1-330): 0: 614: 99.70		PPR27_HUMAN (54-173): 2.16e-21: 93.6: 42.15
+	Hs
		906517 PP1B_HUMAN (1-330): 0: 568: 87.58		PPR27_HUMAN (54-173): 2.16e-21: 93.6: 42.15
+	Hs
		3260 PP1B_HUMAN (1-330): 0: 568: 87.58		A0A0S2Z4Q8_HUMAN (224-322): 2.32e-18: 85.7: 24.27
+	Gg
		907234 PP1B_CHICK (1-330): 0: 568: 87.58		MYPT1_CHICK (200-961): 1.47e-14: 80.7: 11.55