Protein: GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

Gene: GPC6
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q9Y625

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0009966 - regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

283729

GPC4
Glypican-4

4

0

High-throughput

0.846

High

733520

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.667

High

1335413

CAMKV
CaM kinase-like vesicle-associated protein

3

3

High-throughput

0.662

High

1102782

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

8

Small-scale

0.647

High

1371156

DLX4
Homeobox protein DLX-4

2

0

High-throughput

0.602

High

1490900

RT07
Small ribosomal subunit protein uS7m

2

1

High-throughput

0.574

High

829612

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

7

High-throughput

0.549

High

193654

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

3

High-throughput

0.536

High

437848

HEPS
Serine protease hepsin

1

11

High-throughput

0.536

High

1395237

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

1

2

High-throughput

0.536

High

1418369

TMPSD
Transmembrane protease serine 13

1

12

High-throughput

0.536

High

1459696

MLX
Max-like protein X

1

1

High-throughput

0.536

High

1491778

ST14
Suppressor of tumorigenicity 14 protein

1

11

High-throughput

0.536

High

423551

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.501

High

884290

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.489

High

1177909

CL12B
C-type lectin domain family 12 member B

1

6

High-throughput

0.489

High

1290442

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

13

High-throughput

0.489

High

1326472

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.489

High

279554

TULP3
Tubby-related protein 3

1

4

High-throughput

0.479

High

426971

FGF1
Fibroblast growth factor 1

1

8

High-throughput

0.479

High

905349

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

1005295

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1045960

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1049074

REL
Proto-oncogene c-Rel

1

4

High-throughput

0.479

High

1194493

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1217579

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

3

High-throughput

0.479

High

1367704

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

934037

PLTP
Phospholipid transfer protein

1

0

High-throughput

0.458

High

1192301

ZACN
Ligand-gated cation channel ZACN

1

0

High-throughput

0.458

High

1450340

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.458

High

216030

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.445

High

328210

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

584172

FOSL2
Fos-related antigen 2

1

2

High-throughput

0.445

High

868320

P2RY1
P2Y purinoceptor 1

1

7

High-throughput

0.445

High

883969

CENPF
Centromere protein F

1

3

High-throughput

0.445

High

1040413

DYST
Dystonin

1

3

High-throughput

0.445

High

1239991

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

1326183

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1398274

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

2

High-throughput

0.445

High

1430378

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

1235592

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.437

High

1256293

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

369793

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.426

High

337850

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

936025

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

3

High-throughput

0.407

High

952396

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.407

High

1064054

ECHP
Peroxisomal bifunctional enzyme

1

7

High-throughput

0.407

High

1288341

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

14

High-throughput

0.407

High

1290424

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

13

High-throughput

0.407

High

1231164

SCAR3
Scavenger receptor class A member 3

2

0

High-throughput

0.318

High

1245549

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

0

High-throughput

0.249

Low

1431645

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.249

Low

1392202

RUSF1
RUS family member 1

1

0

High-throughput

0.232

Low

1395882

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.232

Low

1447925

SAR1A
Small COPII coat GTPase SAR1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025