HitPredict

Interactor 1: PP1A (P62137)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: Ppp1ca

Interactor 2: TSC1 (Q9EP53)
Hamartin (Tuberous sclerosis 1 protein homolog)
Gene: TSC1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	29669786, 17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Mm			1 1161
+	Mm
		915338 PP2AB_MOUSE (8-302): 1.41e-176: 492: 48.31		TSC1_MOUSE (1-1161): 0: 771: 100.00
+	Hs
		148613 PP1A_HUMAN (1-330): 0: 614: 99.70		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		528366 PP1A_HUMAN (1-330): 0: 614: 99.70		MYH6_HUMAN (395-1133): 3.51e-26: 119: 8.77
+	Mm
		906240 PP1A_MOUSE (1-330): 0: 614: 100.00		MYH6_MOUSE (390-1126): 4.93e-26: 118: 9.95
+	Hs
		724746 PP1A_HUMAN (1-330): 0: 614: 99.70		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		906052 PP1A_HUMAN (1-330): 0: 614: 99.70		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Hs
		148470 PP1G_HUMAN (1-330): 0: 579: 90.36		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		148614 PP1B_HUMAN (1-330): 0: 568: 87.58		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		724689 PP1G_HUMAN (1-330): 0: 579: 90.36		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		724747 PP1B_HUMAN (1-330): 0: 568: 87.58		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Dm
		819289 PP1B_DROME (6-326): 0: 551: 83.18		MYSN_DROME (465-1146): 3.53e-28: 125: 8.59
+	Hs
		906549 PP1B_HUMAN (1-330): 0: 568: 87.58		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Dm
		404229 PP1B_DROME (6-326): 0: 551: 83.18		MYSA_DROME (405-1117): 3.26e-20: 99.9: 10.46
+	Dm
		404244 Q8T0U6_DROME (19-326): 0: 537: 84.09		MYSA_DROME (405-1117): 3.26e-20: 99.9: 10.46
+	Dm
		819254 PP1B_DROME (6-326): 0: 551: 83.18		Q0KI67_DROME (347-872): 2.5e-15: 83.7: 10.02
+	Dm
		1213450 Q8T0U6_DROME (19-326): 0: 537: 84.09		Q8INC3_DROME (347-872): 9.56e-16: 85.3: 10.02
+	Hs
		724764 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.64		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		931058 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.64		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		725131 PP2AB_HUMAN (8-302): 1.41e-176: 492: 48.31		MYH10_HUMAN (617-910): 9.54e-10: 65.3: 13.27
+	Hs
		930850 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.64		SLMAP_HUMAN (681-959): 6.71e-09: 62.5: 20.13