HitPredict

Interactor 1: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: TPM4 (P67936)
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
Gene: TPM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 327 Hs			1 248
+	Hs
		451229 PP1B_HUMAN (1-327): 0: 597: 100.00		TPM1_HUMAN (4-248): 1.43e-48: 163: 68.16
+	Hs
		110799 PP1B_HUMAN (1-327): 0: 597: 100.00		H7BYY1_HUMAN (1-248): 8.1e-49: 162: 77.82
+	Hs
		418931 PP1B_HUMAN (1-327): 0: 597: 100.00		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Hs
		434366 PP1B_HUMAN (1-327): 0: 597: 100.00		TPM2_HUMAN (4-248): 5.04e-42: 146: 69.39
+	Hs
		418899 PP1G_HUMAN (1-327): 0: 569: 86.89		TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39
+	Hs
		737733 PP1G_HUMAN (1-327): 0: 569: 86.89		TPM4_HUMAN (1-248): 5.49e-47: 158: 100.00
+	Dm
		451124 PP1B_DROME (1-322): 0: 568: 90.37		TPM2_DROME (5-246): 7.24e-38: 135: 42.98
+	Dm
		419100 PP1B_DROME (1-322): 0: 568: 90.37		TPM1_DROME (7-241): 5.05e-09: 57.7: 24.68