HitPredict

Interactor 1: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: PPR3B (Q86XI6)
Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)
Gene: PPP1R3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.613

Property	Details
Experiments	23414517, 36949045
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005977 - glycogen metabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 285
+	Hs
		906001 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR3B_HUMAN (1-285): 1.65e-132: 378: 100.00
+	Hs
		737903 PP1G_HUMAN (1-327): 0: 569: 86.89		PPR3B_HUMAN (1-285): 1.65e-132: 378: 100.00
+	Hs
		906639 PP1B_HUMAN (1-327): 0: 597: 100.00		PPR3C_HUMAN (1-284): 6.48e-115: 335: 40.00
+	Hs
		906203 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR3C_HUMAN (1-284): 6.48e-115: 335: 40.00
+	Hs
		738131 PP1G_HUMAN (1-327): 0: 569: 86.89		PPR3C_HUMAN (1-284): 6.48e-115: 335: 40.00
+	Hs
		906477 PP1B_HUMAN (1-327): 0: 597: 100.00		PPR3A_HUMAN (2-253): 1.55e-82: 270: 26.36
+	Hs
		905933 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR3A_HUMAN (2-253): 1.55e-82: 270: 26.36
+	Mm
		906352 PP1A_MOUSE (1-326): 0: 576: 88.49		PPR3A_MOUSE (3-253): 1.86e-81: 267: 26.74
+	Hs
		737831 PP1G_HUMAN (1-327): 0: 569: 86.89		PPR3A_HUMAN (2-253): 1.55e-82: 270: 26.36
+	Ce
		109596 GLC7B_CAEEL (1-326): 0: 580: 86.02		H2KYT5_CAEEL (55-285): 9.66e-80: 247: 31.56
+	Hs
		319093 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR3D_HUMAN (16-240): 2.47e-82: 251: 30.60
+	Ce
		821923 GLC7B_CAEEL (1-326): 0: 580: 86.02		Q400N3_CAEEL (55-285): 2.01e-79: 245: 31.56
+	Mm
		57204 PP1A_MOUSE (1-326): 0: 576: 88.49		A2AJW4_MOUSE (12-240): 5.29e-81: 247: 27.43
+	Hs
		319090 PP1G_HUMAN (1-327): 0: 569: 86.89		PPR3D_HUMAN (16-240): 2.47e-82: 251: 30.60
+	Dm
		819280 PP1B_DROME (1-322): 0: 568: 90.37		Q8SWT8_DROME (60-285): 5.74e-80: 246: 34.47
+	Dm
		819218 PP11_DROME (6-327): 0: 567: 85.09		Q8SWT8_DROME (60-285): 5.74e-80: 246: 34.47
+	Hs
		81860 PP1A_HUMAN (1-326): 0: 576: 88.79		PP13G_HUMAN (19-236): 1.66e-63: 205: 22.78
+	Hs
		906138 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR3E_HUMAN (23-248): 9.69e-65: 205: 25.65
+	Dm
		819327 PP1B_DROME (1-322): 0: 568: 90.37		GBS76_DROME (35-268): 2.11e-62: 210: 29.17
+	Hs
		737884 PP1G_HUMAN (1-327): 0: 569: 86.89		PPR3F_HUMAN (26-233): 9.08e-49: 174: 20.91