HitPredict

Interactor 1: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 530
+	Hs
		913328 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369310 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369327 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369311 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		587150 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		611411 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		500362 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		RARB_HUMAN (49-529): 1.02e-113: 346: 23.92
+	Hs
		510012 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65
+	Hs
		530791 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		RARG_HUMAN (68-525): 2.18e-107: 330: 24.18
+	Hs
		906980 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		ERR3_HUMAN (60-499): 2.69e-106: 327: 30.29
+	Hs
		487934 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		907008 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		611412 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		907027 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		HNF4G_HUMAN (148-520): 5.7e-102: 314: 24.40
+	Hs
		487292 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Dm
		186127 PRS8_DROME (57-433): 1.81e-127: 376: 46.95		Q8WS79_DROME (134-368): 4.91e-45: 167: 38.15
+	Dm
		186158 PRS8_DROME (57-433): 1.81e-127: 376: 46.95		Q9VSE9_DROME (134-368): 7.21e-45: 166: 38.15
+	Hs
		487299 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		437631 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03
+	Hs
		487293 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59