HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: PRS10 (P62333)
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
Gene: PSMC6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 28292943, 35271311, 35235311, 28514442, 32296183, 33961781, 11361004, 37071682, 22275368, 19490896, unassigned1304, 16763564
Identification Methods pull down, affinity chromatography technology, cross-linking study, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, anti bait coimmunoprecipitation, validated two hybrid
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB, AAA_lid_3~AAA_lid_3, Prot_ATP_ID_OB~Prot_ATP_ID_OB
Common GO terms GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 8 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 406
Hs

1 389
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+ Dm
+ Dm
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+ Rn
+ Af
+ Dm
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+ Rn

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Last updated: 15 Jul 2024