HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: ERR3 (P62508)
Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
Gene: ESRRG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	15604093, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 458
+	Hs
		587150 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85
+	Hs
		500362 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARB_HUMAN (34-455): 1.84e-121: 363: 28.37
+	Hs
		369311 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61
+	Rn
		411261 PRS8_RAT (1-406): 1.42e-136: 398: 100.00		ESR1_RAT (32-457): 8.57e-112: 343: 33.48
+	Hs
		487934 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARA_HUMAN (62-455): 5.97e-112: 339: 28.92
+	Hs
		369310 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61
+	Hs
		611412 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR4A1_HUMAN (42-454): 8.47e-108: 333: 29.16
+	Hs
		510012 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ERR1_HUMAN (38-456): 1.2e-109: 332: 55.32
+	Hs
		907008 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR1H3_HUMAN (41-457): 3.23e-109: 332: 23.64
+	Hs
		530791 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARG_HUMAN (59-455): 2.33e-106: 324: 31.13
+	Hs
		907027 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		HNF4G_HUMAN (120-454): 5.91e-106: 322: 26.87
+	Hs
		611411 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		NR4A1_HUMAN (42-454): 8.47e-108: 333: 29.16
+	Hs
		369145 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61
+	Hs
		369100 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61
+	Hs
		907111 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50
+	Hs
		906889 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50
+	Hs
		798727 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50
+	Hs
		730322 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50
+	Dm
		186127 PRS8_DROME (8-123): 6.29e-11: 65.5: 7.76		Q8WS79_DROME (125-455): 3.23e-80: 258: 43.28
+	Dm
		186158 PRS8_DROME (8-123): 6.29e-11: 65.5: 7.76		Q9VSE9_DROME (125-455): 4.42e-80: 258: 43.28