HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: MARH8 (Q5T0T0)
E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8)
Gene: MARCHF8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	30759391, 14722266
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 291
+	Hs
		849338 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		MARH8_HUMAN (1-291): 1.77e-109: 320: 100.00
+	Hs
		895806 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		MARH8_HUMAN (1-291): 1.77e-109: 320: 100.00
+	Hs
		849378 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		MARH1_HUMAN (5-291): 6.93e-84: 255: 64.46
+	Hs
		849469 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		MARH4_HUMAN (66-287): 3.22e-64: 209: 23.32
+	Hs
		1199325 UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08		MARH3_HUMAN (55-253): 1.93e-48: 163: 24.26
+	Hs
		849466 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		MARH2_HUMAN (48-257): 8.13e-49: 164: 25.82
+	Hs
		919767 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		MARH3_HUMAN (55-253): 1.93e-48: 163: 24.26
+	Hs
		895832 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		MARH3_HUMAN (55-253): 1.93e-48: 163: 24.26
+	Hs
		1199317 UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33		MARH3_HUMAN (55-253): 1.93e-48: 163: 24.26
+	Hs
		851833 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		MARH3_HUMAN (55-253): 1.93e-48: 163: 24.26
+	Hs
		919880 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		MARH5_HUMAN (80-240): 5.93e-34: 126: 18.97
+	Hs
		849461 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		MARH5_HUMAN (80-240): 5.93e-34: 126: 18.97
+	Hs
		895930 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		MARH5_HUMAN (80-240): 5.93e-34: 126: 18.97
+	Hs
		231862 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		MARH6_HUMAN (72-212): 3.3e-29: 118: 28.37
+	Hs
		1282354 UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00		MARH5_HUMAN (80-240): 5.93e-34: 126: 18.97
+	Hs
		851894 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		MARH5_HUMAN (80-240): 5.93e-34: 126: 18.97
+	Hs
		919864 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		MARH7_HUMAN (44-132): 2.12e-14: 75.3: 30.39
+	Hs
		849448 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		MARH7_HUMAN (44-132): 2.12e-14: 75.3: 30.39
+	Hs
		895915 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		MARH7_HUMAN (44-132): 2.12e-14: 75.3: 30.39
+	Hs
		851887 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		MARH7_HUMAN (44-132): 2.12e-14: 75.3: 30.39