HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: M3K10 (Q02779)
Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)
Gene: MAP3K10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9427749, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 954
+	Hs
		909438 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77
+	Hs
		909655 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59
+	Hs
		789053 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ABL2_HUMAN (5-935): 7.45e-135: 436: 17.33
+	Hs
		909795 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ULK2_HUMAN (97-884): 2.01e-132: 426: 18.53
+	Hs
		337416 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ABL1_HUMAN (5-950): 1.72e-126: 412: 18.02
+	Hs
		910094 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K20_HUMAN (89-897): 1.97e-127: 406: 21.34
+	Mm
		910278 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		TAOK2_MOUSE (71-915): 4.41e-120: 397: 15.39
+	Hs
		909810 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MINK1_HUMAN (98-925): 6.77e-114: 382: 16.47
+	At
		965327 14332_ARATH (4-255): 1.05e-147: 414: 74.41		PBS1_ARATH (28-463): 5.24e-127: 393: 20.52
+	At
		965320 14332_ARATH (4-255): 1.05e-147: 414: 74.41		BAK1_ARATH (58-410): 8.93e-120: 380: 23.16
+	Hs
		411661 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		LCK_HUMAN (2-372): 3.86e-113: 359: 25.00
+	At
		788521 14333_ARATH (1-253): 3.45e-147: 413: 74.12		PBL9_ARATH (53-362): 1.21e-119: 372: 22.77
+	Hs
		201290 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K7_HUMAN (83-355): 2.87e-45: 175: 38.49