HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: RHG21 (Q5T5U3)
Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)
Gene: ARHGAP21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1958
+	Hs
		70666 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MYO9A_HUMAN (397-1626): 2.37e-163: 559: 13.41
+	Hs
		909866 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARAP2_HUMAN (461-1674): 2.78e-114: 404: 13.08
+	Mm
		910284 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		RHG33_MOUSE (813-1719): 4.74e-92: 330: 14.94
+	Hs
		909659 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SYDE2_HUMAN (609-1382): 2.99e-90: 323: 13.69
+	Hs
		909743 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRGP1_HUMAN (1015-1671): 1.5e-88: 316: 18.66
+	Hs
		64684 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RHG32_HUMAN (975-1909): 3.2e-84: 310: 16.63
+	Mm
		910285 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRGP3_MOUSE (1010-1639): 2.01e-86: 310: 17.76
+	Mm
		910322 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRGP2_MOUSE (652-1769): 1.01e-85: 307: 13.69
+	Hs
		253335 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRGP2_HUMAN (652-1769): 9.4e-84: 302: 13.96
+	Hs
		909637 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		Q5JSD8_HUMAN (1160-1285): 4.53e-68: 226: 89.68
+	Hs
		506563 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		BCR_HUMAN (1142-1311): 4.29e-23: 110: 40.00