HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: CRTC3 (Q6UUV7)
CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)
Gene: CRTC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 619
+	Hs
		909630 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CRTC2_HUMAN (2-619): 2.13e-52: 193: 35.62
+	Hs
		909700 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CRTC1_HUMAN (7-619): 1.18e-40: 159: 31.55
+	Rn
		910356 1433E_RAT (1-255): 4.87e-154: 430: 100.00		CRTC1_RAT (7-619): 1.06e-37: 150: 30.66
+	Mm
		910268 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		CRTC1_MOUSE (7-619): 1.74e-36: 146: 30.51
+	Hs
		297821 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		K0754_HUMAN (232-614): 1.23e-22: 105: 9.20
+	Hs
		909712 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		OTOG_HUMAN (224-610): 1.9e-16: 85.9: 14.21